Case-cohort study of plasma phospholipid fatty acid profiles, cognitive function, and risk of dementia: a secondary analysis in the Ginkgo Evaluation of Memory Study
Case-cohort study of plasma phospholipid fatty acid profiles, cognitive function, and risk of dementia: a secondary analysis in the Ginkgo Evaluation of Memory Study
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DOI：
10.1093/ajcn/nqab087
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发表时间：
2021-04-21
影响因子：
7.1
通讯作者：
Jensen, Majken K.
中科院分区：
文献类型：
--
作者：
Koch, Manja;Furtado, Jeremy D.;Jensen, Majken K.
背景：磷脂是膳食脂肪摄入和代谢的生物标志物。与几种心脏代谢紊乱有关很少有前瞻性研究评估了血浆磷脂与痴呆风险和认知functions.Objectives：我们的目的是评估之间的关联减少亚油酸伴随着增加其他脂肪酸和认知功能和痴呆risk.Methods：我们进行了嵌套的银杏评价记忆研究的病例队列研究。共有1252名参与者。其中498人在平均5年的随访期间发生痴呆。我们通过GC测量了45个个体的血浆磷脂（占总血浆磷脂脂肪酸的百分比），并将其与基线时的改良简易精神状态检查（3 MSE）评分和神经学家裁定的全因痴呆和阿尔茨海默病（AD）发生率相关。结果：用1%的SFA替代1%的亚油酸（主要的多不饱和n-6（omega-6）脂肪酸），与痴呆症的高风险相关（每1% SFA替代亚油酸的HR = 1.03; 95% CI：1.00，1.07），基线时3 MSE评分降低0.08分（95% CI：-0.12，-0.03），表示认知功能较差。与亚油酸相比，我们没有发现总单不饱和脂肪酸、n-3多不饱和脂肪酸或反式脂肪酸与痴呆或AD的风险相关。然而，用1%的海洋n-3 PUFA DHA替代亚油酸与痴呆风险降低相关（HR = 0.86/1% DHA替代亚油酸; 95% CI：0.76，0.96）。载脂蛋白E基因型没有改变这些关联。轻度认知功能障碍的基线，年龄，或sex.Conclusions：特定的元素的饮食可能与晚年痴呆症，一个假设，需要正式测试的随机对照试验，这是一个可能的预防干预。
Background: Phospholipids are biomarkers of dietary fat intake and metabolism. linked to several cardiometabolic disorders. Few prospective studies have assessed plasma phospholipids in relation to dementia risk and cognitive function.Objectives: We aimed to evaluate the association between a decrease in linoleic acid accompanied with an increase in other fatty acids and cognitive function and dementia risk.Methods: We conducted a case-cohort study nested within the Ginkgo Evaluation of Memory Study. We included 1252 participants. 498 of whom who developed dementia during a mean of 5 y of follow-up. We measured 45 individual plasma phospholipids (as a percentage of total plasma phospholipid fatty acids) by GC and related these to Modified Mini-Mental State Examination (3MSE) scores at baseline and neurologist-adjudicated incidence of all-cause dementia and Alzheimer disease (AD). adjusting for sociodemographic and clinical characteristics.Results: Substitution of 1% of SFAs for 1% of linoleic acid, the predominant polyunsaturated n-6 (omega-6) fatty acid, was associated with higher risk of dementia (HR per 1% of SFAs instead of linoleic acid = 1.03; 95% CI: 1.00, 1.07) and a 0.08 point lower 3MSE score at baseline (95% CI: -0.12, -0.03), signifying worse cognitive function. When compared with linoleic acid, we found no associations of total monounsaturated, n-3 polyunsaturated, or trans fatty acids with risk of dementia or AD. However, the substitution of 1% of the marine n-3 PUFA DHA for linoleic acid was associated with lower risk of dementia (HR = 0.86 per 1% of DHA instead of linoleic acid; 95% CI: 0.76, 0.96). These associations were not modified by apolipoprotein E genotype. mild cognitive impairment at baseline, age, or sex.Conclusions: Specific elements of diet may be associated with late-life dementia, a hypothesis that requires formal testing in randomized controlled trials and that represents a possible preventive intervention.