Informant-Reported Cognitive Decline is Associated with Objective Cognitive Performance in Parkinson's Disease.
Informant-Reported Cognitive Decline is Associated with Objective Cognitive Performance in Parkinson's Disease.
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知情者报告的认知下降与帕金森病的客观认知表现相关。
DOI：
10.1017/s1355617720001137
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Schiehser,DawnM
中科院分区：
文献类型：
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作者：
Nakhla,MarinaZ;Holiday,KelseyA;Filoteo,JVincent;Zlatar,ZvinkaZ;Malcarne,VanessaL;Lessig,Stephanie;Litvan,Irene;Schiehser,DawnM
目的基于信息的认知衰退测量方法能否准确描述帕金森病（PD）无痴呆患者的客观认知表现尚不确定。由于这些信息的临床相关性，本研究的目的是研究通过老年人认知衰退问卷（IQCODE）的患者认知能力下降与非痴呆PD控制认知状态（即轻度认知障碍；PD- mci和正常认知；PD- nc）的客观认知之间的关系。方法：139名非痴呆PD参与者（PD- mci n = 38; PD- nc n = 101）接受语言、执行功能、注意力、学习、延迟回忆、视觉空间功能、情绪和运动功能的测量。每个参与者都确定了一个信息提供者来完成IQCODE和情绪问卷。结果：在IQCODE中，患者认知能力下降的基于信息的反应水平越高，与总体样本中整体认知、注意力、学习、延迟回忆和执行功能的客观表现越差显著相关，超出协变量和认知状态。然而，IQCODE与语言或视觉空间功能没有显着关联。结果表明，通过IQCODE测量的信息反馈可以提供关于非痴呆PD的广泛认知能力的足够信息，包括MCI和正常认知的PD。研究结果对IQCODE在识别需要进一步评估、监测和治疗的PD患者中的应用具有重要的临床意义。
ObjectiveThe utility of informant-based measures of cognitive decline to accurately describe objective cognitive performance in Parkinson’s disease (PD) without dementia is uncertain. Due to the clinical relevance of this information, the purpose of this study was to examine the relationship between informant-based reports of patient cognitive decline via the Informant Questionnaire of Cognitive Decline in the Elderly (IQCODE) and objective cognition in non-demented PD controlling for cognitive status (i.e., mild cognitive impairment; PD-MCI and normal cognition; PD-NC).MethodOne-hundred and thirty-nine non-demented PD participants (PD-MCI n = 38; PD-NC n = 101) were administered measures of language, executive function, attention, learning, delayed recall, visuospatial function, mood, and motor function. Each participant identified an informant to complete the IQCODE and a mood questionnaire.ResultsGreater levels of informant-based responses of patient cognitive decline on the IQCODE were significantly associated with worse objective performance on measures of global cognition, attention, learning, delayed recall, and executive function in the overall sample, above and beyond covariates and cognitive status. However, the IQCODE was not significantly associated with language or visuospatial function.ConclusionsResults indicate that informant responses, as measured by the IQCODE, may provide adequate information on a wide range of cognitive abilities in non-demented PD, including those with MCI and normal cognition. Findings have important clinical implications for the utility of the IQCODE in the identification of PD patients in need of further evaluation, monitoring, and treatment.