REGIONAL CEREBRAL GLUCOSE METABOLIC-RATE IN HUMAN SLEEP ASSESSED BY POSITRON EMISSION TOMOGRAPHY
REGIONAL CEREBRAL GLUCOSE METABOLIC-RATE IN HUMAN SLEEP ASSESSED BY POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1016/0024-3205(89)90021-0
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发表时间：
1989-01-01
期刊：
影响因子：
6.1
通讯作者：
BUNNEY, WE
中科院分区：
文献类型：
--
作者：
BUCHSBAUM, MS;GILLIN, JC;BUNNEY, WE
用正电子发射断层扫描和18氟标记2-脱氧葡萄糖(FDG)测定了36名正常志愿者夜间睡眠时的脑葡萄糖代谢率。与清醒对照组相比，在非快速眼动(NREM)睡眠(主要是第二阶段和第三阶段)期间服用FDG的受试者整个大脑的代谢率降低了约23%。额叶的下降幅度大于颞叶或枕叶，基底节和丘脑的下降幅度大于皮质。处于快速眼动(REM)睡眠状态的受试者的皮质代谢率往往高于清醒受试者。与清醒时相比，快速眼动睡眠时，扣带回是唯一显示葡萄糖代谢率显著增加的皮质结构。REM睡眠时，右侧基底节相对较活跃，NREM睡眠时基底节相对对称。
The cerebral metabolic rate of glucose was measured during nighttime sleep in 36 normal volunteers using positron emission tomography and fluorine-18-labeled 2-deoxyglucose (FDG). In comparison to waking controls, subjects given FDG during non-rapid eye movement (NREM) sleep (primarily stages 2 and 3) showed about a 23% reduction in metabolic rate across the entire brain. This decrease was greater for the frontal than temporal or occipital lobes, and greater for basal ganglia and thalamus than cortex. Subjects in rapid eye movement (REM) sleep tended to have higher cortical metabolic rates than waking subjects. The cingulate gyrus was the only cortical structure to show a significant increase in glucose metabolic rate in REM sleep in comparison to waking. The basal ganglia were relatively more active on the right in REM sleep and symmetrical in NREM sleep.