Entrainment of activity to multiple feeding times in rats with suprachiasmatic lesions
Entrainment of activity to multiple feeding times in rats with suprachiasmatic lesions
复制标题
视交叉上病变大鼠的多次喂养活动夹带
DOI：
10.1016/0031-9384(89)90026-7
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发表时间：
1989
影响因子：
2.9
通讯作者：
F. Stephan
中科院分区：
文献类型：
--
作者：
F. Stephan
在SCN损伤的大鼠中研究了每天两次或三次食物获取时间的车轮运行的夹带。当间隔8小时提供两次喂食时间（每次1.5小时）时，所有大鼠均被带入。预期活动（AA）的第二次喂食时间大大减少时，间隔减少到5小时。一个8小时的相位延迟一个喂食时间导致延迟瞬变和AA的未转移的时间表随之减少。7只大鼠每天维持3次喂食时间（每次1小时），间隔为6-6-12小时，然后间隔8-8-8小时。6只大鼠对三个访问时间中的两个显示出一些AA，但没有大鼠同时预期所有3个访问时间。AA偶尔会从一个访问时间切换到另一个访问时间。在所有条件下，夹带是不太稳定相比，单次访问时间。通常，AA中的不稳定性暗示了瞬变，即，暂时失去夹带。结果似乎与由2个内部耦合起搏器组成的模型最一致，该起搏器通过进食被携带。
Entrainment of wheel running to two or three food access times per day was investigated in rats with SCN lesions. When two feeding times (1.5 hr each) were presented 8 hr apart, all rats entrained to both. Anticipatory activity (AA) to the second feeding time was greatly diminished when the interval was reduced to 5 hr. An 8 hr phase delay of one feeding time resulted in delaying transients and a concomitant reduction of AA to the unshifted schedule. Seven rats were maintained on 3 feeding times (1 hr each) per day at 6-6-12 hr intervals, followed by 8-8-8 hr intervals. Six rats displayed some AA to two of three access times, but no rat anticipated all 3 access times simultaneously. AA occasionally shifted from one access time to another. In all conditions, entrainment was much less stable compared to single access times. Typically, the instabilities in AA were suggestive of transients, i.e., a temporary loss of entrainment. The results appear most consistent with a model consisting of 2 internally coupled pacemakers that are entrained by feeding.