Toxic shock syndrome: role of the environment, the host and the microorganism.
Toxic shock syndrome: role of the environment, the host and the microorganism.
复制标题
中毒性休克综合征：环境、宿主和微生物的作用。
DOI：
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发表时间：
1996
影响因子：
1.9
通讯作者：
Chance Td
中科院分区：
文献类型：
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作者：
Chance Td
中毒性休克综合征是一种以发热、皮疹和低血压为特征的疾病，可能危及生命。它于1978年首次被描述，自那时以来，已经描述了许多病例，并注意到与月经期间的不适有关。在许多情况下，有并发感染产毒素金黄色葡萄球菌。然而，现在已经清楚，情况更加复杂：该综合征可能发生在成人和儿童中，男女都有，并且可能在感染了除沙门氏菌之外的细菌之后发生。金黄色。中毒性休克综合征需要易感宿主、产毒细菌和宿主内正确的生长条件的组合。所涉及的一种或多种毒素的作用已证明难以阐明。最有希望的理论认为，所涉及的毒素作为超级抗原，导致大量的T淋巴细胞增殖，并产生细胞因子白细胞介素-1和肿瘤坏死因子。
Toxic shock syndrome is a condition characterised by fever, rash and hypotension, and can be life-threatening. It was first described in 1978, since when many cases have been described and an association with tampon use during menstruation noted. In many cases there was concurrent infection with toxin-producing Staphylococcus aureus. It has since become clear, however, that the situation is more complex: the syndrome may occur in adults and children of both sexes, and may follow infection with bacteria other than S. aureus. Toxic shock syndrome requires a combination of susceptible host, toxin-producing bacterium and the right growth conditions within the host. The action of the toxin or toxins involved has proved difficult to elucidate. The most promising theory proposes that the toxins involved act as super-antigens, which cause massive T-lymphocyte proliferation, and production of the cytokines interleukin-1 and tumour necrosis factor.