Serum total bilirubin levels and prevalence of diabetic retinopathy in a Chinese population
Serum total bilirubin levels and prevalence of diabetic retinopathy in a Chinese population
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DOI：
10.1111/1753-0407.12085
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发表时间：
2014-05-01
影响因子：
4.5
通讯作者：
Ning, Guang
中科院分区：
文献类型：
--
作者：
Najam, Syeda Sadia;Sun, Jichao;Ning, Guang
背景2型糖尿病（T2 D）患者发生微血管并发症的风险很高，如糖尿病视网膜病变（DR）。先前的研究表明，T2 D患者的低血清胆红素浓度可能会增加糖尿病并发症的风险。因此，本研究的目的是探讨DR的患病率和血清总胆红素浓度之间的关联在中国population.MethodsThe本研究是一项基于人口的横断面研究1761 T2 D患者年龄40岁，来自上海嘉定区，中国。拍摄眼底照片以确认DR的存在和严重程度。基于血清总胆红素浓度将受试者分配到四分位数（四分位数（Q）1 0.99 mg/dL）。Logistic回归模型被用来探讨胆红素浓度和DR的患病率之间的关联。结果DR的患病率在整个研究人群为9.6%。与其他三个四分位数相比，第4季度的DR患病率显著较低（P趋势=0.004）。调整多个混杂因素后，Q4（即血清胆红素> 0.99 mg/dL）的T2 D患者发生DR的可能性低于Q1（即血清胆红素0.99 mg/dL）的患者（比值比0.55; 95%置信区间0.33-0.91），物流？9.6%，三个？(?? P = 0.004）？(OR= 0.55，95%？CI0.33-0.91）？
BackgroundPatients with type 2 diabetes (T2D) are at a high risk of developing microvascular complications, such as diabetic retinopathy (DR). Previous studies have shown that low serum bilirubin concentrations in T2D patients may increase the risk of diabetic complications. Thus, the aim of the present was to investigate the association between the prevalence of DR and serum concentrations of total bilirubin in a Chinese population.MethodsThe present study was a population-based cross-sectional study on 1761 T2D patients aged 40 years from the Jiading district of Shanghai, China. Fundus photographs were taken to confirm the presence and severity of DR. Subjects were assigned to quartiles based on serum total bilirubin concentrations (Quartile (Q) 1 0.99mg/dL). Logistic regression models were used to explore the association between bilirubin concentrations and the prevalence of DR.ResultsThe prevalence of DR in the entire study population was 9.6%. The prevalence of DR was significantly lower in Q4 compared with the other three quartiles (P-trend=0.004). After adjustment for multiple confounding factors, T2D patients in Q4 (i.e. serum bilirubin >0.99mg/dL) were less likely (odds ratio 0.55; 95% confidence interval 0.33-0.91) to suffer from DR than patients in Q1 (i.e. serum bilirubin 0.99 mg/dL),????????????Logistic?????????????????????????????????????????9.6%???????????????????????????????????3?(??P = 0.004)??????????,???????????????????,?????????????????????????????????(OR = 0.55,95%????CI0.33-0.91)?????????,???????????????????????????,??????????????????????