RESTORATION OF EXCITATION-CONTRACTION COUPLING AND SLOW CALCIUM CURRENT IN DYSGENIC MUSCLE BY DIHYDROPYRIDINE RECEPTOR COMPLEMENTARY-DNA
RESTORATION OF EXCITATION-CONTRACTION COUPLING AND SLOW CALCIUM CURRENT IN DYSGENIC MUSCLE BY DIHYDROPYRIDINE RECEPTOR COMPLEMENTARY-DNA
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DOI：
10.1038/336134a0
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发表时间：
1988-11-10
期刊：
影响因子：
64.8
通讯作者：
NUMA, S
中科院分区：
文献类型：
--
作者：
TANABE, T;BEAM, KG;NUMA, S
显微注射携带编码骨骼肌二氢吡啶类钙通道阻滞剂受体的互补DNA的表达质粒，可恢复肌肉发育不全小鼠培养的骨骼肌细胞中的兴奋-收缩偶联和慢钙电流。这表明骨骼肌横小管膜上的二氢吡啶受体既是兴奋-收缩偶联的电压传感器，又是慢钙通道。
Microinjection of an expression plasmid that carries complementary DNA encoding the receptor for dihydropyridine calcium channel blockers of skeletal muscle restores both excitation-contraction coupling and slow calcium current in cultured skeletal muscle cells from mice with muscular dysgenesis. This suggests that the dihydropyridine receptor in the transverse tubule membrane of skeletal muscle functions both as the voltage sensor for excitation–contraction coupling and as the slow calcium channel.