Functional peptide KP24 enhances submandibular gland tissue growth in vitro
Functional peptide KP24 enhances submandibular gland tissue growth in vitro
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DOI：
10.1016/j.reth.2016.02.006
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发表时间：
2016-03-01
影响因子：
4.3
通讯作者：
Matsumoto, Takuya
中科院分区：
文献类型：
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作者：
Ikeda, Atsushi;Taketa, Hiroaki;Matsumoto, Takuya
简介：唾液腺功能减退症，也称为口干症，是头颈癌、自身免疫性疾病或衰老的放射治疗的结果。口腔干燥症导致口腔健康问题，从而影响生活质量。体外生物唾液腺组织的产生将提供一种替代模式的治疗这种疾病。方法：为了开发一种新的方法来调节唾液腺组织的生长在体外，我们制备了一种固定KP24肽的水凝胶片，其中肽包含重复的脯氨酸和赖氨酸序列，并评估这种肽对唾液腺组织生长的影响。我们发现，KP24肽具有增强体外腺组织生长的潜力。结论：KP24肽修饰材料是一种很有前途的体外调节涎腺组织生长的材料。(C)2016年，日本再生医学会。制作和主办：Elsevier B.V.
Introduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects the quality of life. Biological salivary gland tissue generated in vitro would provide an alternative mode of treatment for this disease.Methods: To develop a novel method for modulating salivary gland tissue growth in vitro, we prepared a KP24 peptide-immobilized hydrogel sheet, wherein the peptide comprised repeating proline and lysine sequences, and evaluated the effect of this peptide on salivary gland tissue growth.Results: We found that the KP24 peptide has the potential to enhance glandular tissue growth in vitro. This enhancement is associated with neurite outgrowth and increasing neural innervation.Conclusion: KP24 peptide modified material would be a promising material for the modulation of salivary gland tissue growth in vitro. (C) 2016, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.