Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli.
Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli.
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DOI：
10.1007/s00253-018-9200-5
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发表时间：
2018-09
影响因子：
5
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Li M;Nian R;Xian M;Zhang H
最近对异戊二烯和异戊烯醇的生物技术生产进行了研究。异戊二烯目前主要由石油制成，是合成农药、药物、石油添加剂、香料等的重要平台化学品，在橡胶生产工业中尤其重要。异戊烯醇比众所周知的生物燃料（乙醇）具有更好的燃烧性能，最近受到更多关注。石油作为异戊二烯和异戊烯醇的传统来源，其供应是不可持续的，化学合成过程可能会导致严重的环境问题。作为替代方案，在细胞工厂中生物合成异戊二烯和异戊烯醇更加可持续且环保。与其他微生物相比，大肠杆菌具有许多优势，被认为是生产这些化合物的强大主力生物。本综述将重点介绍异戊二烯和异戊烯醇生产代谢工程的最新进展，特别是使用大肠杆菌细胞工厂。
The biotechnological production of isoprene and isopentenol has recently been studied. Isoprene, which is currently made mainly from petroleum, is an important platform chemical for synthesizing pesticides, medicines, oil additives, fragrances, and more and is especially important in the rubber production industry. Isopentenols, which have better combustion properties than well-known biofuels (ethanol), have recently received more attention. Supplies of petroleum, the conventional source of isoprene and isopentenols, are unsustainable, and chemical synthesis processes could cause serious environmental problems. As an alternative, the biosynthesis of isoprene and isopentenols in cell factories is more sustainable and environmentally friendly. With a number of advantages over other microorganisms, Escherichia coli is considered to be a powerful workhorse organism for producing these compounds. This review will highlight the recent advances in metabolic engineering for isoprene and isopentenol production, especially using E. coli cell factories.
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