22.8 Multi-Functional Microelectrode Array System Featuring 59,760 Electrodes, 2048 Electrophysiology Channels, Impedance and Neurotransmitter Measurement Units.
22.8 Multi-Functional Microelectrode Array System Featuring 59,760 Electrodes, 2048 Electrophysiology Channels, Impedance and Neurotransmitter Measurement Units.
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DOI：
10.1109/isscc.2016.7418073
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发表时间：
2016-02-25
期刊：
影响因子：
--
通讯作者：
Hierlemann A
中科院分区：
文献类型：
--
作者：
Viswam V;Dragas J;Shadmani A;Chen Y;Stettler A;Müller J;Hierlemann A
近年来，各种基于CMOS的微电极阵列（MEA）已经被开发用于产电细胞的胞外电生理记录/刺激。主要使用了两种方法：（i）有源像素方法（APS），其特征在于所有电极的同时读出，然而，以极高的噪声水平为代价，以及（ii）开关矩阵（SM）方法，其产生更好的噪声性能，而仅电极的子集（例如，第1024章同时出手所有系统最多具有电压记录和/或电压/电流刺激功能。
Various CMOS-based micro-electrode arrays (MEAs) have been developed in recent years for extracellular electrophysiological recording/stimulation of electrogenic cells. Mostly two approaches have been used: (i) the activepixel approach (APS), which features simultaneous readout of all electrodes, however, at the expense of a comparably high noise level, and (ii) the switchmatrix (SM) approach, which yields better noise performance, whereas only a subset of electrodes (e.g.,1024) is simultaneously read out. All systems feature, at most, voltage recording and/or voltage/current stimulation functionalities.