OBSERVATIONS ON PATHOGENESIS OF PORCINE PARVOVIRUS INFECTION
OBSERVATIONS ON PATHOGENESIS OF PORCINE PARVOVIRUS INFECTION
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DOI：
10.1007/bf01317841
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发表时间：
1976-01-01
影响因子：
2.7
通讯作者：
JOHNSON, RH
中科院分区：
文献类型：
--
作者：
JOO, HS;DONALDSONWOOD, CR;JOHNSON, RH
猪细小病毒（PPV）的发病机制在经口感染和经口感染的妊娠后备母猪中存在差异。经口感染后，PPV需要23-32天才能穿过胎盘，而经口感染后只需15天。只有在妊娠中期，经口感染后备母猪才会成功穿过胎盘；在妊娠1、2个月时，母体感染可导致胎儿感染。胎儿感染导致死亡和木乃伊化，只有在感染发生在免疫能力开始之前（约为0.1%）。妊娠期70天)。受感染的胎儿在免疫能力开始前死亡或存活以引起免疫反应，随后死亡或存活至分娩。PPV导致的生殖失败，以干化或偶尔死产为特征，本质上可能与口腔感染有关，仅在妊娠中期的前半段感染时发生。
Differences in the pathogenesis of porcine parvovirus (PPV) were shown in pregnant gilts infected orally and i.m. Orally, PPV took 23-32 days to cross the placenta following infection of the dam, compared to 15 days i.m. Successful transplacental infection occurred following oral infection of dams only in the 2nd trimester of gestation; i.m. infection resulted in infection of fetuses in 1st and 2nd trimesters of gestation. Fetal infection resulted in death and mummification only where infection occurred before onset of immune competence (at .apprx. 70 days gestation). Infected fetuses died before onset of immune competence or survived to mount an immune response with subsequent death or survival to farrowing. Reproductive failure due to PPV, characterized by mummification or occasional stillbirth, may be associated in nature with oral infection and occur only when dams are infected in the 1st part of the midthird of gestation.