INHERITANCE OF ALLELIC BLUEPRINTS FOR METHYLATION PATTERNS
INHERITANCE OF ALLELIC BLUEPRINTS FOR METHYLATION PATTERNS
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DOI：
10.1016/0092-8674(88)90546-6
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发表时间：
1988-07-15
期刊：
影响因子：
64.5
通讯作者：
WHITE, R
中科院分区：
文献类型：
--
作者：
SILVA, AJ;WHITE, R
我们已经开发出一种策略来区分组织中同源染色体的甲基化模式，并在人类谱系中遵循这些模式。这种遗传学方法揭示了同源染色体上等位基因位点甲基化变异的证据。这种变异是组织特异性的，并且在通过生殖系传递后是可重复的，这表明同源染色体具有不同的甲基化组织特异性调控蓝图。 此外，该方法可用于研究亲本印迹与哺乳动物基因座甲基化之间的关系。
We have developed a strategy to distinguish between the methylation patterns of homologous chromosomes in tissues, and to follow these patterns in human pedigrees. This genetic approach uncovered evidence of variation in the methylation of allelic sites on homologous chromosomes. This variation was tissue-specific and reproducible after transmission through the germ line, demonstrating that homologous chromosomes have distinct blueprints for the tissue-specific regulation of methylation. Furthermore, this approach can be used to study the relationship between parental imprinting and methylation in native mammalian loci.