Transplant-related mortality and long-term graft function are significantly influenced by cell dose in patients undergoing allogeneic marrow transplantation
Transplant-related mortality and long-term graft function are significantly influenced by cell dose in patients undergoing allogeneic marrow transplantation
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DOI：
10.1182/blood-2002-01-0339
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发表时间：
2002-12-01
期刊：
影响因子：
20.3
通讯作者：
Bacigalupo, A
中科院分区：
文献类型：
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作者：
Dominietto, A;Lamparelli, T;Bacigalupo, A
我们研究了905例接受非操作异基因骨髓移植（BMT）的患者的细胞剂量对短期和长期移植物功能和结果的影响，这些患者来自HLA相同的同胞（n = 735），单抗原不匹配的相关供体（n = 35）或匹配的无关供体（n = 135）。输注的有核细胞中位数为3.4 × 108/kg（第25百分位数为2.4 × 108/kg，第75百分位数为5 × 108/kg）。根据输注的细胞将患者分为3组：小于或等于2.4 × 10（8）/kg（n = 247;低剂量）; >2.4 × 10（8）/kg且小于或等于5 × 10（8）/kg（n = 452;中等剂量）;和>5 × 10（8）/kg（n = 206;高剂量）。接受高细胞剂量的患者在BMT后+20、+50、+100、+180和+365天的血小板计数显著升高（P
We have studied the impact of cell dose on short- and long-term graft function and outcome in 905 patients undergoing an unmanipulated allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling (n = 735), a one-antigen mismatched related donor (n = 35), or a matched unrelated donor (n = 135). Median number of nucleated cells infused was 3.4 x 10(8)/kg (25th percentile 2.4 x 10(8)/kg, 75th percentile 5 x 108/kg). Patients were stratified according to cells infused in 3 groups: less than or equal to 2.4 x 10(8)/kg (n = 247; low dose); >2.4 x 10(8)/kg and less than or equal to 5 x 10(8)/kg (n = 452; intermediate dose); and >5 x 10(8)/kg (n = 206; high dose). Patients receiving high cell dose had significantly higher platelet counts on days +20, +50, +100, +180, and +365 after BMT (P