Structural investigations of cross-linked hyaluronan
Structural investigations of cross-linked hyaluronan
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DOI：
10.1016/s0142-9612(01)00231-9
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发表时间：
2002-02-01
期刊：
影响因子：
14
通讯作者：
Bevilacqua, C
中科院分区：
文献类型：
--
作者：
Gamini, A;Paoletti, S;Bevilacqua, C
几个交联的透明质酸衍生物，通过扫描电子显微镜，一维NMR显微镜和同步辐射的小角X-射线散射获得的结构特性，并与未改性的透明质酸，用作参考材料所观察到的。在不同介质中获得的实验结果显示了合成基质的一致性。尤其是。通过电子显微镜观察到的较致密聚合物材料区域的存在导致本体水质子的较高横向弛豫速率以及通过NMR显微镜获得的扩散系数的降低。此外，聚合物结区的存在下引起的外观的散射X-辐射的强度的图案中的一个定义明确的相关峰。(C)2001爱思唯尔科技有限公司版权所有。
Structural properties of several cross-linked hyaluronan derivatives, obtained by scanning electron microscopy, monodimensional NMR microscopy and small angle X-ray scattering of synchrotron radiation, are presented and compared with those observed for non-modified hyaluronic acid, used as a reference material. The experimental results, obtained in different media, showed a consistent picture of the synthesized matrices. In particular. the presence of zones of denser polymeric material observed by electron microscopy resulted in a higher transversal relaxation rate of the bulk water protons as well as in a decrease of the diffusion coefficient obtained by NMR microscopy. Moreover, the presence of polymer junction zones gave rise to the appearance of a well-defined correlation peak in the pattern of intensity of the scattered X-radiation. (C) 2001 Elsevier Science Ltd. All rights reserved.