Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations
Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations
复制标题
DOI：
10.1038/sj.ejcn.1602097
复制
发表时间：
2005-04-01
影响因子：
4.7
通讯作者：
Ueland, PM
中科院分区：
文献类型：
--
作者：
de Bree, A;van der Put, N;Ueland, PM
背景：高同型半胱氨酸血症（HHCY）是心血管疾病（CVD）的危险因素。HHCY可能与高血压（HTEN）和不利的胆固醇谱（UNFAVCHOL）相互作用以改变CVD.Objectives的风险：评估HHCY（1）单独和（2）与UNFAVCHOL和/或HTEN组合在不同年龄组中的患病率。为了提供信息，可能会提高筛选和治疗的受试者在风险cvod.Design：横断面数据12 541名男性和12 948名女性年龄20+y被用于从9个欧洲study.Results：孤立HHCY的患病率为8.5%，年龄在20- 40岁的受试者，4.7%，年龄在40- 60岁的受试者和5.9%，年龄在60岁以上的受试者。当合并所有年龄组时，5.3%患有单独的HHCY，另外5.6%患有HHCY与HTEN和/或UNFAVCHOL的组合。危险因素的组合随着年龄的增长而增加，除了HHCY和UNFAVCHOL，比偶然预测的更普遍。在年轻受试者（20- 40岁）中，24%患有一种或多种研究的CVD风险因素。老年受试者（60岁以上）的这一数字为75.1%。结论：选定的欧洲人群中有相当多的受试者患有HHCY（10.9%）。在这些病例中，有一半的受试者还患有其他CVD风险因素，如UNFAVCHOL和HTEN。特别是老年人往往有一个以上的风险因素。医疗保健专业人员在筛查和治疗老年人时应该意识到这一点，不仅针对传统的CVD风险因素，如UNFAVCHOL和HTEN，而且还针对HHCY，因为这可以通过补充剂或强化叶酸的食物增加叶酸的摄入量来轻松减少。
Background: Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular diseases (CVD). HHCY may interact with hypertension (HTEN) and an unfavorable cholesterol profile (UNFAVCHOL) to alter the risk of CVD.Objectives: To estimate the prevalences of HHCY (1) isolated and (2) in combination with UNFAVCHOL and/or HTEN in different age categories. To provide information that may improve the screening and treatment of subjects at risk of CVD.Design: Cross-sectional data on 12 541 men and 12 948 women aged 20+y were used from nine European studies.Results: The prevalence of isolated HHCY was 8.5% in subjects aged 20-40y, 4.7% in subjects aged 40-60y and 5.9% in subjects aged over 60y. When combining all age groups, 5.3% had isolated HHCY and an additional 5.6% had HHCY in combination with HTEN and/or UNFAVCHOL. The combinations of risk factors increased with age and, except for HHCY&UNFAVCHOL, were more prevalent than predicted by chance. Of the young subjects (20-40y), 24% suffered from one or more of the investigated CVD risk factors. This figure was 75.1% in the old subjects (60+years).Conclusions: A substantial number of subjects in selected European populations have HHCY (10.9%). In half of these cases, subjects suffer also from other CVD risk factors like UNFAVCHOL and HTEN. Older people in particular tend to have more than one risk factor. Healthcare professionals should be aware of this when screening and treating older people not only for the conventional CVD risk factors like UNFAVCHOL and HTEN but also HHCY, as this can easily be reduced through increased intake of folic acid via supplement or foods fortified with folic acid.