SCLERODERMA - CURRENT UNDERSTANDING OF PATHOGENESIS AND MANAGEMENT
SCLERODERMA - CURRENT UNDERSTANDING OF PATHOGENESIS AND MANAGEMENT
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DOI：
10.1080/00325481.1981.11715861
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发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
WASNER, CK
中科院分区：
文献类型：
--
作者：
PHILLIPS, RM;WASNER, CK
硬皮病是一种结缔组织疾病。皮肤改变是其最突出的特征，但胃肠道、肾脏。肺或心脏也可能受累。胶原蛋白增加是这种疾病的标志，尽管所有受影响的器官都存在血管变化。人们很难轻易地接受威廉·奥斯勒爵士在1896年对硬皮病患者困境的经典描述，即”被包裹在一层不断收缩、缓慢收缩的钢铁皮肤中“。“一个
Scleroderma is a disease of the connective tissue. Skin change is its most prominent feature, but the gastrointestinal tract, kidney. lung, or heart may also be involved. Increased collagen is a hallmark of this disorder, although vascular changes are present in ali affected organs. One cannot easily sm-pass Sir W1lliam Osler's classic description in 1896 of the plight of a scleroderma pattent as one" encased in an evershrtnking slowly contracttng skin of steel." 1