The initial pathogenesis of cadmium induced renal toxicity
The initial pathogenesis of cadmium induced renal toxicity
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DOI：
10.1016/s0014-5793(00)01843-3
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发表时间：
2000-07-28
期刊：
影响因子：
3.5
通讯作者：
Nicholson, JK
中科院分区：
文献类型：
--
作者：
Griffin, JL;Walker, LA;Nicholson, JK
魔角旋转H-1核磁共振波谱的新应用，结合模式识别技术，已经确定了在经典肾毒性之前脂质和谷氨酸代谢的生化变化。这些变化发生在长期给药后，在低水平暴露和肾CD2+浓度（8.4 μ g/g干wt）下，比WHO临界器官浓度（200 μ g/g湿wt）低近两个数量级。Cd2+对肾组织生物化学的这些早期影响可能反映了对毒性损伤的适应机制或毒理学级联的初步阶段，(C) 2000年欧洲生化学会联合会。Elsevier Science B.V.版权所有。
The novel application of magic angle spinning H-1 NMR spectroscopy, coupled with pattern recognition techniques, has identified biochemical changes in lipid and glutamate metabolism that precede classical nephrotoxicity. These changes occurred in the bank vole (Clethrionomys glareolus) after chronic dosing, at a low level of exposure and at a renal CD2+ concentration (8.4 mu g/g dry wt) that was nearly two orders of magnitude below the WHO critical organ concentration (200 mu g/g wet wt). These early stage effects of Cd2+ on the biochemistry of renal tissue may reflect adaptation mechanisms to the toxic insult or the preliminary stages of the toxicological cascade, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.