Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis.
Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis.
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DOI：
10.1371/journal.pone.0142565
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Whincup PH
中科院分区：
文献类型：
--
作者：
Barone-Adesi F;Dent JE;Dajnak D;Beevers S;Anderson HR;Kelly FJ;Cook DG;Whincup PH
人们普遍关注与交通有关的空气污染可能对健康造成的影响。二氧化氮（NO2）是一种方便的一次污染标志物。我们调查了伦敦儿童肺功能与当前住宅暴露于一系列空气污染物（特别是NO2、NO、NOx和颗粒物）之间的关系。此外，我们将NO2的结果与已发表的相关估计的荟萃分析相结合。主要交通污染物和肺功能之间的关系进行了调查，在4884名9-10岁的儿童参加了儿童心脏和健康研究在英格兰（CHASE）。系统性文献检索确定了13项符合纳入荟萃分析的研究。我们将荟萃分析的结果与CHASE中FEV 1值的分布相结合，以估计在不同NO2暴露情景下预期肺功能异常（FEV 1 <预测值的80%）的儿童的患病率。在CHASE中，除臭氧外，所有污染物与FEV 1和FVC之间均无显著负相关。在荟萃分析中，NO2增加10 μg/m3与FEV 1降低8 ml相关（95% CI：-14至-1 ml; p：0.016）。观察到的效应未因报告的哮喘诊断而改变。根据这些结果，NO2水平增加10 μg/m3将导致肺功能异常儿童的患病率增加7%（95%CI：4%至12%）。暴露于交通污染可能会导致肺功能的总体小幅下降，并增加儿童临床相关肺功能下降的患病率。
There is widespread concern about the possible health effects of traffic-related air pollution. Nitrogen dioxide (NO2) is a convenient marker of primary pollution. We investigated the associations between lung function and current residential exposure to a range of air pollutants (particularly NO2, NO, NOx and particulate matter) in London children. Moreover, we placed the results for NO2 in context with a meta-analysis of published estimates of the association. Associations between primary traffic pollutants and lung function were investigated in 4884 children aged 9–10 years who participated in the Child Heart and Health Study in England (CHASE). A systematic literature search identified 13 studies eligible for inclusion in a meta-analysis. We combined results from the meta-analysis with the distribution of the values of FEV1 in CHASE to estimate the prevalence of children with abnormal lung function (FEV1<80% of predicted value) expected under different scenarios of NO2 exposure. In CHASE, there were non-significant inverse associations between all pollutants except ozone and both FEV1 and FVC. In the meta-analysis, a 10 μg/m3 increase in NO2 was associated with an 8 ml lower FEV1 (95% CI: -14 to -1 ml; p: 0.016). The observed effect was not modified by a reported asthma diagnosis. On the basis of these results, a 10 μg/m3 increase in NO2 level would translate into a 7% (95% CI: 4% to 12%) increase of the prevalence of children with abnormal lung function. Exposure to traffic pollution may cause a small overall reduction in lung function and increase the prevalence of children with clinically relevant declines in lung function.