Genome-wide linkage scan for physical activity levels in the Quebec Family study.
Genome-wide linkage scan for physical activity levels in the Quebec Family study.
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DOI：
10.1249/01.mss.0000078937.22939.7e
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发表时间：
2003-08
影响因子：
4.1
通讯作者：
R. Simonen;T. Rankinen;L. Pérusse;T. Rice;D. Rao;Y. Chagnon;C. Bouchard
中科院分区：
文献类型：
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作者：
R. Simonen;T. Rankinen;L. Pérusse;T. Rice;D. Rao;Y. Chagnon;C. Bouchard
目的与方法体力活动水平具有家族聚集性。然而，基因和序列变异负责的家族聚类尚未调查。我们进行了全基因组连锁扫描的基础上，在767名受试者分型的432个标记，从207个家庭的魁北克家庭研究的目的是确定影响体力活动水平的基因座。使用了四种身体活动水平表型。结果在染色体2 p22-p16上发现了与运动缺乏相关的连锁证据（P < 0.0023）。不活动（7p11.2，20q13.1）、总体力活动（13 q22-q31）、中度至剧烈体力活动（4q28.2，7p11.2，9q31.1，13 q22-q31）和体力活动时间（11 p15和15q13.3）之间存在暗示性联系（0.0023<P < 0.01）。结论：本研究确定了几个染色体区域携带的基因可能有助于身体活动或久坐的倾向。
PURPOSE AND METHODS It is commonly recognized that there is familial aggregation for physical activity level. However, the genes and sequence variants responsible for the familial clustering have not been investigated. We performed a genome-wide linkage scan based on 432 markers typed in 767 subjects from 207 families of the Quebec Family study with the aim of identifying loci affecting physical activity levels. Four physical activity level phenotypes were used. RESULTS Promising evidence of linkage (P < 0.0023) was found for physical inactivity on chromosome 2p22-p16. Suggestive linkages (0.0023<P < 0.01) were found for inactivity (7p11.2, 20q13.1), total physical activity (13q22-q31), moderate to strenuous physical activity (4q28.2, 7p11.2, 9q31.1, 13q22-q31), and time spent in physical activity (11p15 and 15q13.3). CONCLUSION This study identified several chromosomal regions harboring genes that may contribute to the propensity to be physically active or sedentary.