Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implication for limbic-striatal interactions
Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implication for limbic-striatal interactions
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DOI：
10.1037/0735-7044.110.1.60
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发表时间：
1996-02-01
影响因子：
1.9
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Burns, LH;Annett, L;Robbins, TW
双侧兴奋性毒性病变的3个主要来源的传入腹侧纹状体（神经核）的影响进行了比较开放的领域测试的食物neophobia允许熟悉和新颖的食物之间的选择。而基底外侧杏仁核和腹侧下托的病变在减少食物新恐惧症方面具有定性相似的效果（尽管不影响进食的潜伏期），杏仁核病变增加，腹侧下托减少运动活动。相比之下，腹内侧前边缘前额叶皮层的损伤只影响最初的食物选择和潜伏期措施。相比之下，兴奋性毒性病变的神经核本身和神经内注入的N-甲基-D-天冬氨酸（NMDA）受体拮抗剂AP 5增加活动和衰减的食物新恐惧症。结果进行了讨论的边缘和前额叶神经元网络的作用，收敛在脑桥核控制不同方面的行为反应的新奇性。
The effects of bilateral excitotoxic lesions of 3 major sources of afferents to the ventral striatum (nucleus accumbens) were compared on an open field test of food neophobia allowing the choice between familiar and novel food. Whereas lesions of the basolateral amygdala and ventral subiculum had qualitatively similar effects to reduce food neophobia (although not affecting the latency to eat), amygdala lesions increased and the ventral subiculum decreased locomotor activity. In contrast, damage to the ventromedial prelimbic prefrontal cortex only affected initial food choice and latency measures. By comparison, excitotoxic lesions of the nucleus accumbens itself and intra-accumbens infusion of the N-methyl-D-aspartate (NMDA) receptor antagonist AP5 increased activity and attenuated food neophobia. Results are discussed in terms of the role of limbic and prefrontal neuronal networks converging in the nucleus accumbens to control different aspects of the behavioral response to novelty.