The anxiolytic effect on the fear-potentiated startle is not due to a non-specific disruption
The anxiolytic effect on the fear-potentiated startle is not due to a non-specific disruption
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DOI：
10.1016/s0024-3205(98)00507-4
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发表时间：
1998-11-13
期刊：
影响因子：
6.1
通讯作者：
Olivier, B
中科院分区：
文献类型：
--
作者：
Joordens, RJE;Hijzen, TH;Olivier, B
在本研究中，阿普唑仑，利氮卓，乙醇和氟哌啶醇在士的宁加强惊吓反应范式的影响进行了研究。因为士的宁增加了控制惊吓水平，而没有恐惧条件反射，所以不存在恐惧的中心状态。当抗焦虑药物减少恐惧诱导的惊吓反应增强而不减少士的宁诱导的惊吓增强时，它们在恐惧增强的惊吓反应范例中对惊吓增强的减弱作用更可能归因于它们的抗焦虑特性。在早期研究中有效降低恐惧诱导的惊吓增强的所选药物确实没有选择性地影响士的宁诱导的惊吓增强，支持以下观点：在恐惧增强的惊吓反应范例中，由于抗焦虑药物导致的惊吓增强的剂量依赖性降低并不反映惊吓行为的“非特异性”破坏。
In the present study, the effects of alprazolam, chlordiazepoxide, ethanol and haloperidol in the strychnine-potentiated startle response paradigm were investigated. Because strychnine increases control startle levels without fear-conditioning, no central state of fear exists. When anxiolytic drugs reduce the fear-induced potentiation of the startle response without reducing the strychnine-induced startle potentiation, their attenuating effect on startle potentiation in the fear-potentiated startle response paradigm can more likely be attributed to their anxiolytic properties. The selected drugs, which effectively reduced the fear-induced startle potentiation in an earlier study, indeed did not selectively affect the strychnine-induced startle potentiation, supporting the notion that the dose-dependent reduction of startle potentiation due to anxiolytic drugs in the fear-potentiated startle response paradigm does not reflect a "non-specific" disruption of startle behavior.