Semen quality of industrial workers occupationally exposed to chromium
Semen quality of industrial workers occupationally exposed to chromium
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DOI：
10.1539/joh.47.424
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发表时间：
2005-09-01
影响因子：
3
通讯作者：
Saiyed, HN
中科院分区：
文献类型：
--
作者：
Kumar, S;Sathwara, NG;Saiyed, HN
共61名受试者职业暴露于铬的工业生产硫酸铬和15个控制对象从附近的工业，不生产任何铬相关的化合物进行了研究。通过访谈将每个受试者的病史记录在预先设计的表格上，并进行常规医学检查。采集血液样本（5-6 ml）用于估计铬，采集精液样本用于精液分析和精浆中铜和锌水平的测定。临床检查显示，暴露组有10名受试者（共61名）出现鼻穿孔，而对照组无受试者。与对照组相比，在接触工人的血液中观察到显着更高的铬水平。精浆中锌的浓度低于对照组，而铜的浓度高于对照组。然而，这些变化没有统计学意义。与对照组相比，在接触组中观察到形态异常精子的数量在统计学上显著较高。对数据的进一步分析表明，约53%的接触受试者显示出低于30%的正常形态，而对照受试者为10%。然而，精液量，液化时间，平均pH值，精子活力，浓度或活力，没有显着的改变，铬接触和非接触工人之间。数据还表明，铬暴露对人类精子有一定影响，因为在合并对照组和暴露组的所有数据后，观察到精子形态异常百分比与血铬水平（p=0.016）之间存在显著正相关（r=0.301）。
A total of sixty-one subjects occupationally exposed to chromium in an industry which manufactures chromium sulphate and fifteen control subjects from a nearby industry which does not manufacture any chromium related compounds were studied. The history of each subject was recorded on pre-designed form through interview and a routine medical examination was carried out. Blood samples (5-6 ml) were collected for the estimation of chromium and semen samples were collected for semen analysis and the determination of copper and zinc levels in the seminal plasma. Clinical examination revealed nasal perforation in 10 subjects (out of 61) in the exposed group as compared to none in the control group. A significantly higher level of chromium was observed in the blood of the exposed workers as compared to the control. The concentration of zinc in seminal plasma was lower while the level of copper was higher in the exposed group as compared to the control. However, these changes were not statistically significant. Statistically significant higher numbers of morphologically abnormal sperms were noticed in the exposed group with respect to the control. Further analysis of the data indicated that about 53% of the exposed subjects showed less than 30% normal forms as compared to 10% in control subjects. However, no significant alterations in semen volume, liquefaction time, mean pH value, sperm viability, concentration or motility, were noticed between chromium exposed and unexposed workers. The data also indicates that exposure to chromium has some effect on human sperm as a significant positive correlation (r=0.301) was observed between percentages of abnormal sperm morphology and blood chromium levels (p=0.016) after pooling all the data of the control and exposure groups.