Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4
Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4
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DOI：
10.1088/0031-9155/51/23/011
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发表时间：
2006-12-07
影响因子：
3.5
通讯作者：
Greiner, Walter
中科院分区：
文献类型：
--
作者：
Pshenichnov, Igor;Mishustin, Igor;Greiner, Walter
基于GEANT 4工具包（8.0版），在重离子治疗的蒙特卡罗模型（MCHIT）内计算了PMMA体模中正电子发射核的深度分布。计算的C-11，C-10和O-15核的总产生率与实验数据和FLUKA和POSGEN程序的相应结果进行了比较。通过模拟不稳定核的放射性衰变和正电子在周围介质中的输运，得到了e（+）湮没点的分布。正电子发射断层扫描（PET）的有限的空间分辨率考虑在一个简化的方式。计算了PET扫描仪所见的β（+）-活性的深度分布，并与PMMA体模的可用数据进行了比较。所获得的β（+）-活性分布与质子和C-12束在适合于粒子治疗的能量下的PET数据非常一致。证明了MCHIT预测不同化学组成的组织样材料中的β（+）活性和剂量分布的能力。
Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for heavy-ion therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of C-11, C-10 and O-15 nuclei are compared with experimental data and with corresponding results of the FLUKA and POSGEN codes. The distributions of e(+) annihilation points are obtained by simulating radioactive decay of unstable nuclei and transporting positrons in the surrounding medium. A finite spatial resolution of the positron emission tomography ( PET) is taken into account in a simplified way. Depth distributions of beta(+)-activity as seen by a PET scanner are calculated and compared to available data for PMMA phantoms. The obtained beta(+)-activity profiles are in good agreement with PET data for proton and C-12 beams at energies suitable for particle therapy. The MCHIT capability to predict the beta(+)-activity and dose distributions in tissue-like materials of different chemical composition is demonstrated.