Adult Stem Cells in the Treatment of Acute Myocardial Infarction
Adult Stem Cells in the Treatment of Acute Myocardial Infarction
复制标题
DOI：
10.1002/ccd.22620
复制
发表时间：
2011-01-01
影响因子：
2.3
通讯作者：
Vanderheyden, Marc
中科院分区：
文献类型：
--
作者：
Sharif, Faisal;Bartunek, Jozef;Vanderheyden, Marc
干细胞治疗已成为早期和终末期左室功能障碍的一种新的治疗方法。快速转化为临床试验留下了许多未解之谜。此外，急性心肌梗死随机试验的结果是有争议的，强调需要进一步的基础和转化研究，以提高对细胞功能的理解。本文综述了与细胞治疗相关的一些功能问题，并对干细胞临床试验的现状进行了评价。尽管迄今为止的结果显示左心室功能有适度的改善，但进展应该遵循一个协调的、多学科的、精心设计的途径，以解决细胞归巢、细胞保留的问题，并关注生理参数之外的结果。(C) 2010 Wiley-Liss, Inc。
Stem cell therapy has emerged as a novel therapeutic treatment alternative for early and end stage LV dysfunction. The rapid translation into clinical trials has left many questions unanswered. Moreover, results of randomized trials in the setting of acute myocardial infarction are controversial, emphasizing a need for further basic and translational research to improve understanding of cell functionality. This review attempts to summarize some of the functional issues related to cell therapy and also evaluate the current status of stem cell clinical trials. Although results to date have shown modest improvement in left ventricular function, the progress should follow a coordinated, multidisciplinary, and well designed path to address issues of cell homing, cell retention, and also look at outcomes beyond physiological parameters. (C) 2010 Wiley-Liss, Inc.