Salicylic acid-derived poly(anhydride-esters) inhibit bone resorption and formation in vivo
Salicylic acid-derived poly(anhydride-esters) inhibit bone resorption and formation in vivo
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DOI：
10.1002/jbm.a.30184
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发表时间：
2005-03-15
影响因子：
4.9
通讯作者：
Uhrich, KE
中科院分区：
文献类型：
--
作者：
Harten, RD;Svach, DJ;Uhrich, KE
本研究的目的是研究一种新型聚合物生物降解成水杨酸（SA）对临界尺寸长骨缺损愈合的影响。将均聚物微球，或含有少50% SA的共聚物，装入大鼠股骨中骨干缺损的5mm内。对照动物接受胶原海绵植入。植入4周和8周后，采用显微放射照相和定量组织形态测量法评估骨愈合情况。术后4周，两组新骨形成明显减少（p < 0.038）。在这个时候，聚合物也减少了骨质流失，尽管没有统计学意义。然而，在术后8周，与对照组相比，两组的骨质流失均有统计学意义上的显著减少（p < 0.0072）。两种聚合物似乎引起相同的组织反应，因为在任何时间点均聚物和共聚物材料之间没有检测到差异。这些结果表明，局部释放的SA可以显著减少该动物模型的骨质流失和骨形成。(C) 2005 Wiley期刊有限公司
The objective of this study was to investigate the effects of a novel polymer that biodegrades into salicylic acid (SA) on the healing of critical sized long bone defects. Microspheres of the homopolymer, or a copolymer containing 50% less of the SA, were packed into 5-mm mid-diaphyseal defects in rat femurs. Control animals received collagen sponge implants. After 4 and 8 weeks of implantation, bone healing was evaluated using microradiography and quantitative histomorphometry. Four weeks postsurgery, significantly less new bone was formed in both of the polymer groups (p < 0.038). Reduced bone loss was also noted with the polymers at this time, although it was not statistically significant. However, at 8 weeks postsurgery, a statistically significant reduction in bone loss was observed in both of the polymer groups compared with controls (p < 0.0072). Both polymers seemed to elicit identical tissue responses because there were no differences detected between the homopolymer and copolymer materials at either time point. These results indicate that locally released SA can significantly reduce both bone loss and bone formation in this animal model. (C) 2005 Wiley Periodicals, Inc.