Smoking cessation is associated with an increase in exhaled nitric oxide
Smoking cessation is associated with an increase in exhaled nitric oxide
复制标题
DOI：
10.1378/chest.112.2.313
复制
发表时间：
1997-08-01
期刊：
影响因子：
9.6
通讯作者：
Daughton, D
中科院分区：
文献类型：
--
作者：
Robbins, RA;Millatmal, T;Daughton, D
研究目的：一氧化氮(NO)是一种由呼吸道细胞产生的气体，据报道吸烟者呼出的空气中一氧化氮(NO)减少。我们假设戒烟会导致呼出NO的增加。设计：比较不吸烟者、吸烟者和戒烟后吸烟者呼出的NO。地点：大学门诊戒烟诊所。患者或参与者：25名吸烟者和23名正常的不吸烟者。干预：呼出的NO通过三种技术测量：(1)峰值口腔法；(2)平均口腔法；(3)鼻口法。吸烟者被给予尼古丁贴片，并被指示在1周和8周后再次吸烟。测量和结果：与不吸烟者相比，吸烟者三种方法测得的NO水平均有所下降(p0.2)，但仍低于正常非吸烟者的平均口腔NO水平(p=0.018)。结论：这些数据表明戒烟与呼出的NO增加有关。
Study objectives: Nitric oxide (NO), a gas produced by cells lining the respiratory tract, has been reported to be decreased in the exhaled air of cigarette smokers. We hypothesized that smoking cessation would result in an increase in exhaled NO.Design: Comparison of exhaled NO measured from nonsmokers, cigarette smokers, and smokers after smoking cessation.Setting: University outpatient smoking cessation clinic.Patients or participants: Twenty-five cigarette smokers and 23 normal, nonsmokers.Interventions: Exhaled NO was measured by three techniques: (1) a peak oral method; (2) a mean oral method; and (3) a nasal method. The smokers were given nicotine patches and instructed to return after 1 and 8 weeks. The exhaled NO determinations were repeated on each visit.Measurements and results: Compared with nonsmokers, smokers had decreased NO levels measured by all three methods (p0.2), but-were still lower than the normal nonsmoker mean oral NO (p=0.018).Conclusions: These data demonstrate that smoking cessation is associated with an increase in exhaled NO.