Resilience and vulnerability: a neurobiological perspective.
Resilience and vulnerability: a neurobiological perspective.
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DOI：
10.12703/p5-13
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
McEwen, Bruce S
中科院分区：
文献类型：
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作者：
Karatsoreos, Ilia N;McEwen, Bruce S
大脑不断适应不断变化的环境。它检测环境刺激，将该信息与内部状态整合，并做出适当的行为和生理反应。这种通过变化实现稳定的过程被称为“变稳态”，它是一种机制，生物体可以通过这种机制适应不断变化的环境，以实现最佳功能，并最终确保生存。通过“弯曲”而不是“破坏”来适应环境中的压力源的能力可以被认为是“弹性”。那些更能承受这种挑战的人，他们的稳定性，并反弹后，可以被认为比那些没有更有弹性。这篇综述将探讨在神经生物学背景下，压力和变稳态的作用，并侧重于神经营养因子，特别是BDNF，在介导适应性可塑性的作用。
The brain is constantly adapting to a changing environment. It detects environmental stimuli, integrates that information with internal states, and engages appropriate behavioral and physiological responses. This process of stability through change is termed "allostasis", and serves as a mechanism by which an organism can adapt to a changing environment to function optimally, and ultimately ensure survival. The ability to adapt to stressors in the environment by "bending" but not "breaking" can be considered as "resilience". Individuals that are more able to withstand such challenges to their stability, and bounce back after, can be considered more resilient than those that do not. This review will explore what resilience means in a neurobiological context, the role of stress and allostasis, and focuses on the role of neurotrophins, particularly BDNF, in mediating adaptive plasticity.