Effect of mechanical strain on solute diffusion in human TMJ discs: an electrical conductivity study.
Effect of mechanical strain on solute diffusion in human TMJ discs: an electrical conductivity study.
复制标题
机械应变对人体 TMJ 盘中溶质扩散的影响：电导率研究。
DOI：
10.1007/s10439-013-0840-4
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发表时间：
2013
影响因子：
3.8
通讯作者：
Yao,Hai
中科院分区：
文献类型：
--
作者：
Wright,GregoryJ;Kuo,Jonathan;Shi,Changcheng;Bacro,ThierryRH;Slate,ElizabethH;Yao,Hai
本研究采用电导法研究了机械应变对人颞下颌关节盘（平均尸体年龄77.8岁）中溶质扩散的影响。导电性，以及小离子扩散率，男性和女性颞下颌关节盘下三个压缩应变。在雄性组中，0%应变时的平均圆盘电导率（平均值± SD）为5.14 ± 0.97 mS/cm，10%应变时降至4.50 ± 0.91 mS/cm（−12.3%），20%压缩应变时降至3.93 ± 0.81 mS/cm（−23.5%）。相应地，0%应变时的平均圆盘相对离子扩散率为0.44 ± 0.08，10%应变时降至0.40 ± 0.08（-8.9%），20%压缩应变时降至0.36 ± 0.08（-16.7%）。在女性组中，0%应变时的平均圆盘电导率为5.84 ± 0.59 mS/cm，10%应变时降至5.01 ± 0.50 mS/cm（−14.2%），20%压缩应变时降至4.33 ± 0.46 mS/cm（−25.8%）。相应地，0%应变时的平均圆盘相对离子扩散率为0.49 ± 0.05，10%应变时降至0.43 ± 0.04（-11.3%），20%压缩应变时降至0.39 ± 0.04（-19.9%）。结果表明，机械应变显着阻碍溶质扩散通过光盘。这种机械应变效应在女性中比在男性人类颞下颌关节盘中更大。这项研究可能为颞下颌关节的病理生理学提供新的见解。
This study investigated the effect of mechanical strain on solute diffusion in human TMJ discs (mean cadaver age 77.8) using the electrical conductivity method. The electrical conductivity, as well as small ion diffusivity, of male and female TMJ discs was determined under three compressive strains. In the male group, the average disc electrical conductivity (mean ± SD) at 0% strain was 5.14 ± 0.97 mS/cm, decreased to 4.50 ± 0.91 mS/cm (−12.3%) at 10% strain, and 3.93 ± 0.81 mS/cm (−23.5%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.44 ± 0.08, decreased to 0.40 ± 0.08 (−8.9%) at 10% strain, and 0.36 ± 0.08 (−16.7%) at 20% compressive strain. In the female group, the average disc electrical conductivity at 0% strain was 5.84 ± 0.59 mS/cm, decreased to 5.01 ± 0.50 mS/cm (−14.2%) at 10% strain, and 4.33 ± 0.46 mS/cm (−25.8%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.49 ± 0.05, decreased to 0.43 ± 0.04 (−11.3%) at 10% strain, and 0.39 ± 0.04 (−19.9%) at 20% compressive strain. The results indicated that mechanical strain significantly impeded solute diffusion through the disc. This mechanical strain effect was larger in the female than in the male human TMJ disc. This study may provide new insights into TMJ pathophysiology.