Effects of cell volume fraction changes on apparent diffusion in human cells
Effects of cell volume fraction changes on apparent diffusion in human cells
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DOI：
10.1016/s0730-725x(00)00147-8
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发表时间：
2000-07-01
影响因子：
2.5
通讯作者：
Gore, JC
中科院分区：
文献类型：
--
作者：
Anderson, AW;Xie, J;Gore, JC
扩散加权成像用于研究细胞悬浮液和填充阵列中明显扩散系数（ADC）和细胞体积分数之间的关系。细胞体积分数通过改变细胞外流体渗透压（对于人神经胶质细胞）以及改变细胞密度（远大的人神经胶质细胞和红细胞）而变化。在填充的神经胶质细胞阵列中，当细胞萎缩时，ADC增加了10％，当细胞肿胀时降低了13％。随着细胞密度从0增加到72％，ADC降低了34％。在红细胞悬浮液中，随着细胞密度从0增加到89％，ADC降低了90％。这些结果与理论预测一致。 （c）2000 Elsevier Science Inc.保留所有权利。
Diffusion-weighted imaging was used to study the relationship between apparent diffusion coefficient (ADC) and cell volume fraction in cell suspensions and packed arrays. Cell volume fraction was varied by changing extracellular fluid osmolarity (for human glial cells) and by changing cell density (far human glial and red blood cells). In packed arrays of glial cells, ADC increased 10% when cells shrank and decreased 13% when cells swelled. ADC decreased 34% as cell density increased from 0 to 72%. In erythrocyte suspensions, ADC decreased 90% as the cell density increased from 0 to 89%. These results agree with theoretical predictions. (C) 2000 Elsevier Science Inc. All rights reserved.