The zebrafish as a model for complex tissue regeneration.
The zebrafish as a model for complex tissue regeneration.
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DOI：
10.1016/j.tig.2013.07.003
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发表时间：
2013-11
影响因子：
11.4
通讯作者：
Poss, Kenneth D.
中科院分区：
文献类型：
--
作者：
Gemberling, Matthew;Bailey, Travis J.;Hyde, David R.;Poss, Kenneth D.
几个世纪以来，哲学家和科学家一直着迷于低等脊椎动物物种再生的原理和含义。两个特点使斑马鱼成为确定再生事件机制的信息模型系统。首先，它们具有高度的再生能力，能够重新生长被切断的鳍，以及受损的大脑，视网膜，脊髓，心脏和其他组织。第二，它们适合正向和反向遗传方法，研究工具集由不断扩大的斑马鱼研究人员社区定期更新。斑马鱼的研究有助于确定多个组织再生的新机制基础，在某些情况下，还可以作为考虑哺乳动物再生策略的指南。在这里，我们回顾了最近的历史，斑马鱼作为一个遗传模型系统，了解如何和为什么组织再生发生。
For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues, and in some cases have served as a guide for contemplating regenerative strategies in mammals. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs.
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