CELLULAR MECHANISM OF NEURONAL SYNCHRONIZATION IN EPILEPSY
CELLULAR MECHANISM OF NEURONAL SYNCHRONIZATION IN EPILEPSY
复制标题
DOI：
10.1126/science.7079735
复制
发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
WONG, RKS
中科院分区：
文献类型：
--
作者：
TRAUB, RD;WONG, RKS
发作间期棘波是一种简单的癫痫神经元活动。场电位和细胞内记录期间观察到的发作间期的棘波青霉素处理的切片的豚鼠海马再现的数学模型的100个海马神经元的区域，包括CA2和CA3的网络。该模型表明，这种形式的神经元同步是由于神经元之间的相互激励而产生的，每个神经元都能够响应于简短的输入而产生内在的爆发。
Interictal spikes are a simple kind of epileptic neuronal activity. Field potentials and intracellular recordings observed during interictal spikes of penicillin-treated slices of the guinea pig hippocampus were reproduced by a mathematical model of a network of 100 hippocampal neurons from the region including CA2 and CA3. The model shows that this form of neuronal synchronization arises because of mutual excitation between neurons, each of which is capable of intrinsic bursting in response to a brief input.