New candidate therapeutic agents for endometrial cancer: potential for clinical practice (review).
New candidate therapeutic agents for endometrial cancer: potential for clinical practice (review).
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DOI：
10.3892/or.2013.2221
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发表时间：
2013-03
期刊：
影响因子：
4.2
通讯作者：
Aoki D
中科院分区：
文献类型：
--
作者：
Umene K;Banno K;Kisu I;Yanokura M;Nogami Y;Tsuji K;Masuda K;Ueki A;Kobayashi Y;Yamagami W;Tominaga E;Susumu N;Aoki D
近年来，子宫内膜癌的病例有所增加，但通过手术、放疗和化疗的联合治疗，患者的预后也得到了改善。然而，从保护生育能力和对复发性和难治性癌症的疗效的角度来看，需要开发新的治疗方法。子宫内膜癌的新候选治疗药物包括抑制子宫内膜腺生长和分化的第四代黄体酮；二甲双胍降低子宫内膜hTERT表达，通过激活AMPK抑制mTOR通路，从而抑制细胞周期；mTOR抑制剂通过G1细胞周期阻滞抑制癌细胞生长；参与肿瘤发生和发展的分子机制的microrna；和HDAC抑制剂，通过肿瘤抑制基因的转录提升、细胞周期阻滞和诱导凋亡来阻断癌细胞的生长。在本研究中，我们回顾了这些药物作为子宫内膜癌新治疗候选药物的背景和早期临床证据。
Cases of endometrial cancer have increased in recent years, but the prognosis of patients with this disease has also been improved by combined modality therapy with surgery, radiotherapy and chemotherapy. However, the development of new therapy is required from the perspectives of conservation of fertility and efficacy for recurrent and intractable cancer. New candidate therapeutic agents for endometrial cancer include fourth-generation progestins for inhibition of growth and differentiation of endometrial glands; metformin for reduction of hTERT expression in the endometrium and inhibition of the mTOR pathway by activation of AMPK, with consequent inhibition of the cell cycle; mTOR inhibitors for supressing growth of cancer cells by G1 cell cycle arrest; microRNAs involved in the molecular mechanisms of oncogenesis and progression; and HDAC inhibitors that block the growth of cancer cells by transcriptional elevation of tumor-suppressor genes, cell cycle arrest and induction of apoptosis. In this study, we review the background and early clinical evidence for these agents as new therapeutic candidates for endometrial cancer.
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