Attitudes about vaccines to prevent Ebola virus disease in Guinea at the end of a large Ebola epidemic: Results of a national household survey
Attitudes about vaccines to prevent Ebola virus disease in Guinea at the end of a large Ebola epidemic: Results of a national household survey
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DOI：
10.1016/j.vaccine.2017.06.026
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发表时间：
2017-12-14
期刊：
影响因子：
5.5
通讯作者：
Marston, Barbara
中科院分区：
文献类型：
--
作者：
Irwin, Kathleen L.;Jalloh, Mohamed F.;Marston, Barbara
2014-2016年，埃博拉疫情肆虐几内亚;世界卫生组织报告了3800多例病例和2500例死亡。2015年8月，随着疫情的消退和实验性埃博拉疫苗的临床试验在几内亚和邻国塞拉利昂继续进行，我们进行了一项关于埃博拉相关知识，态度和实践（KAP）以及对“假设”埃博拉疫苗的看法的全国家庭调查。方法：我们使用整群随机抽样，选择了几内亚8个行政区的15岁以上的参与者，这些行政区有不同的累积病例数。调查问卷评估了社会人口特征、流行期间的经历、埃博拉相关KAP和埃博拉疫苗态度。为了评估在几内亚引入埃博拉疫苗的潜力，我们研究了疫苗的态度和参与者的特征之间的关联使用分类和多变量analysis.Results：6699人邀请参加，94%的人回答至少1个埃博拉疫苗的问题。大多数人同意需要疫苗来抗击疫情（85.8%），如果几内亚可以获得安全有效的埃博拉疫苗，他们的家人会接受（84.2%）。这些感兴趣和可接受性的指标在男性、富裕、受教育程度较高、与接受过常规疫苗的幼儿一起生活的参与者中更为常见。在了解埃博拉传播模式的参与者中，兴趣和可接受性也显着更高，曾目睹埃博拉应对团队，了解埃博拉感染者，相信埃博拉并不总是致命的，并将访问埃博拉治疗中心。在多变量分析的大多数参与者与年幼的儿童，兴趣和可接受性显着较高的那些与接种疫苗的儿童生活在一起比那些与未接种疫苗的儿童。讨论：假设的疫苗的高可接受性表明强大的潜力，在几内亚引进埃博拉疫苗。建立公众对埃博拉疫苗使用信心的战略应强调与几内亚常规使用的安全有效疫苗的任何相似之处。爱思唯尔有限公司出版
Introduction: In 2014-2016, an Ebola epidemic devastated Guinea; more than 3800 cases and 2500 deaths were reported to the World Health Organization. In August 2015, as the epidemic waned and clinical trials of an experimental, Ebola vaccine continued in Guinea and neighboring Sierra Leone, we conducted a national household survey about Ebola-related knowledge, attitudes, and practices (KAP) and opinions about "hypothetical" Ebola vaccines.Mehods:Using cluster-randomized sampling, we selected participants aged 15+ years old in Guinea's 8 administrative regions, which had varied cumulative case counts. The questionnaire assessed socio-demographic characteristics, experiences during the epidemic, Ebola-related KAP, and Ebola vaccine attitudes. To assess the potential for Ebola vaccine introduction in Guinea, we examined the association between vaccine attitudes and participants' characteristics using categorical and multivariable analyses.Results:Of 6699 persons invited to participate, 94% responded to at least 1 Ebola vaccine question. Most agreed that vaccines were needed to fight the epidemic (85.8%) and that their family would accept safe, effective Ebola vaccines if they became available in Guinea (84.2%). These measures of interest and acceptability were significantly more common among participants who were male, wealthier, more educated, and lived with young children who had received routine vaccines. Interest and acceptability were also significantly higher among participants who understood Ebola transmission modes, had witnessed Ebola response teams, knew Ebola-affected persons, believed Ebola was not always fatal, and would access Ebola treatment centers. In multivariable analyses of the majority of participants living with young children, interest and acceptability were significantly higher among those living with vaccinated children than among those living with unvaccinated children.Discussion:The high acceptability of hypothetical vaccines indicates strong potential for introducing Ebola vaccines across Guinea. Strategies to build public confidence in use of Ebola vaccines should highlight any similarities with safe, effective vaccines routinely used in Guinea. Published by Elsevier Ltd.