(S)-9-(2,3-DIHYDROXYPROPYL)ADENINE - ALIPHATIC NUCLEOSIDE ANALOG WITH BROAD-SPECTRUM ANTI-VIRAL ACTIVITY
(S)-9-(2,3-DIHYDROXYPROPYL)ADENINE - ALIPHATIC NUCLEOSIDE ANALOG WITH BROAD-SPECTRUM ANTI-VIRAL ACTIVITY
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DOI：
10.1126/science.200.4341.563
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
DESOMER, P
中科院分区：
文献类型：
--
作者：
DECLERCQ, E;DESCAMPS, J;DESOMER, P
（S）-9-（2，3-二羟丙基）腺嘌呤是一种新型核苷类似物，其糖部分被脂肪链取代，在体外抑制几种DNA和RNA病毒的复制，包括牛痘、单纯疱疹（1型和2型）、麻疹和水疱性口炎。它在体内也能有效降低鼻内接种水泡性口炎病毒的小鼠的死亡率。
(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.