IgG4-related Kidney Disease in Which the Urinalysis, Kidney Function and Imaging Findings Were Normal
IgG4-related Kidney Disease in Which the Urinalysis, Kidney Function and Imaging Findings Were Normal
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DOI：
10.2169/internalmedicine.54.3259
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发表时间：
2015-01-01
影响因子：
1.2
通讯作者：
Tsunoda, Shinichiro
中科院分区：
文献类型：
--
作者：
Otani, Miho;Morinaga, Masahiro;Tsunoda, Shinichiro
IgG 4相关性肾病（IgG 4-related kidney disease，IgG 4 RKD）是一种纤维炎性疾病，以线状纤维化、淋巴浆细胞浸润和高血清IgG 4水平为特征。肾活检是必要的，以诊断IgG 4 RKD的患者没有任何其他器官的病变。肾科医生通常对尿分析异常的患者进行肾活检，如蛋白尿或血尿，或肾衰竭。然而，我们经历了一名IgG 4 RKD患者，尿分析、肾功能或影像学无异常，但有严重的间质性病变。因此，我们建议，肾活检应考虑如果患者没有显示异常尿分析结果，并怀疑有IgG 4 RKD。
IgG4-related kidney disease (IgG4RKD) is recognized as a fibroinflammatory disease characterized by storiform fibrosis, lymphoplasmacytic infiltration and a high serum IgG4 level. A renal biopsy is necessary to diagnose IgG4RKD in patients without any lesions in other organs. Nephrologists typically perform renal biopsies in patients with abnormal urinalysis, such as proteinuria or hematuria, or renal failure. However, we experienced a patient with IgG4RKD without abnormalities in the urinalysis, renal function or imaging, who had severe interstitial lesions. We therefore propose that renal biopsies should be considered if patients do not show abnormal urinalysis findings and are suspected to have IgG4RKD.