The Plasmodium bottleneck: malaria parasite losses in the mosquito vector.
The Plasmodium bottleneck: malaria parasite losses in the mosquito vector.
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DOI：
10.1590/0074-0276130597
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发表时间：
2014-08
影响因子：
2.8
通讯作者：
Jacobs-Lorena M
中科院分区：
文献类型：
--
作者：
Smith RC;Vega-Rodríguez J;Jacobs-Lorena M
每年有近100万人死于疟原虫。虽然致病形式的寄生虫只存在于人类血液中，但按蚊属蚊子是传播的专性载体。在这里，我们回顾了寄生虫的生命周期中的载体，并强调人类和蚊子的贡献，限制疟疾寄生虫在蚊子宿主的发展。我们解决寄生虫杀死蚊子宿主和寄生虫数量的瓶颈，可能会指导干预策略，以防止传播。
Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.
DOI：
10.1073/pnas.0508335102
发表时间：
2005-11-08
影响因子：
11.1
作者：
Abraham, EG;Pinto, SB;Michel, K
通讯作者：
Michel, K