Body impedance is largely dependent on the intra- and extra-cellular water distribution.
Body impedance is largely dependent on the intra- and extra-cellular water distribution.
复制标题
身体阻抗很大程度上取决于细胞内和细胞外的水分分布。
DOI：
--
复制
发表时间：
1989
影响因子：
4.7
通讯作者：
F. Schouten
中科院分区：
文献类型：
--
作者：
P. Deurenberg;K. van der Kooy;R. Leenen;F. Schouten
在空腹血样中进行电阻抗测量，并分析与细胞堆积体积的关系，并计算细胞内和细胞外的水分布。总血液阻抗强烈依赖于细胞内水与总水的比率（r = 0.97，P 小于 0.0001）。在 515 名年龄和身体成分差异较大的受试者中，发现根据去脂体重和身高校正的身体阻抗（特定身体阻抗）与计算出的细胞内水与全身水的比率之间的关系与血液中的关系相似。根据这些观察结果，开发了一个回归模型，并将其应用于几组受试者在因失水而体重减轻之前和之后的身体成分数据。可以在群体水平上计算细胞内和细胞外水分的损失，这证实了该模型的适用性。结论是，根据身体阻抗预测的去脂体重或体内总水分的有效性很大程度上取决于测量对象的水分分布。这意味着必须使用特定于年龄和性别的预测公式来评估身体成分，并且生物电阻抗方法仅谨慎适用于水分布紊乱的受试者，例如水肿、怀孕和脱水。
Electrical impedance measurements were performed in fasting blood samples and analysed in relation to packed cell volume and calculated intra- and extra-cellular water distribution. The total blood impedance was shown to be strongly dependent on the ratio of intra-cellular water to total water (r = 0.97, P less than 0.0001). In a group of 515 subjects, with a large variation in age and body composition, the relation between the body impedence corrected for fat-free mass and body height (the specific body impedance) and the calculated ratio of intra-cellular water to total body water, was found to be similar to that in blood. From these observations a regression model was developed and applied to body compositional data of several groups of subjects before and after weight loss caused by water losses. It was possible to calculate at a group level the losses of intra- and extra-cellular water, which confirms the applicability of the model. It is concluded that the validity of the predicted fat-free mass or total body water from body impedance is largely dependent on the water distribution in the measured subjects. This means that age- and sex-specific prediction formulas have to be used for the assessment of the body composition and that the bio-electrical impedance method is only with caution applicable in subjects with a disturbed water distribution as in oedema, pregnancy and dehydration.