Association of DNMT3b gene variants with sporadic Parkinson's disease in a Chinese Han population
Association of DNMT3b gene variants with sporadic Parkinson's disease in a Chinese Han population
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DNMT3b基因变异与中国汉族人群散发性帕金森病的关联
DOI：
10.1002/jgm.2991
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发表时间：
2017-11-01
影响因子：
3.5
通讯作者：
Xu, Pingyi
中科院分区：
文献类型：
--
作者：
Chen, Xiang;Xiao, Yousheng;Xu, Pingyi
帕金森病 (PD) 是全球第二常见的神经退行性疾病。表观遗传修饰，特别是 DNA 甲基化，与这种疾病的发展有关。 DNA 甲基转移酶 3b (DNMT3b) 是最重要的 DNA 甲基转移酶之一，其遗传变异已被证明与巴西人群的 PD 相关。然而，目前尚不清楚 DNMT3b 的基因变异是否会增加中国汉族患 PD 的风险。本研究旨在探讨 DNMT3b 变体 rs2424913、rs998382 和 rs2424932 与中国汉族人群中 PD 的关系。
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Epigenetic modifications, specifically DNA methylation, have been implicated in the development of this disease. Genetic variants of DNA methyltransferase 3b (DNMT3b), one of the most important DNA methyltransferases, were shown to be associated with PD in a Brazilian population. However, it is unclear whether genetic variants of DNMT3b increase the risk of PD in the Chinese Han people. The present study aimed to investigate the association of the DNMT3b variants rs2424913, rs998382 and rs2424932 with PD in a Chinese Han population.