Effects of nonpolar environments on the redox potentials of heme complexes.
Effects of nonpolar environments on the redox potentials of heme complexes.
复制标题
非极性环境对血红素复合物氧化还原电位的影响。
DOI：
--
复制
发表时间：
1972
影响因子：
11.1
通讯作者：
R. J. Kassner
中科院分区：
文献类型：
--
作者：
R. J. Kassner
本文描述了一种测量非水溶液中氧化还原偶的氧化还原电位的方法。该方法已应用于研究非极性环境对血红素复合物氧化还原电位的影响。与报道的水溶液中相应血红素复合物的氧化还原电位相比，观察到约300 mV的正电位差。我们提出，许多高电位细胞色素的氧化还原电位可能是由非极性氨基酸侧链的低介电常数的局部血红素环境所决定的，并且这个因素可能在决定这些蛋白质的氧化还原特性中起主导作用。
A method has been described for measurement of the oxidation-reduction potentials of redox couples in nonaqueous solutions. This method has been applied to a study of the effect of a nonpolar environment on the redox potential of a heme complex. A positive potential difference of some 300 mV is observed for the measured redox potentials by comparison with reported values for the corresponding heme complex in aqueous solution. The proposal is made that the redox potentials of many high-potential cytochromes may be accounted for by a local heme environment of low-dielectric constant, characteristic of nonpolar amino-acid side chains, and that this factor may play a dominant role in the determination of the oxidation-reduction properties of these proteins.