Moderate use of alcohol, tobacco and cannabis during pregnancy: New approaches and update on research findings
Moderate use of alcohol, tobacco and cannabis during pregnancy: New approaches and update on research findings
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DOI：
10.1016/j.reprotox.2009.04.010
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Huizink, Anja C.
中科院分区：
文献类型：
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作者：
Huizink, Anja C.
在过去的十年中，对不良后代结局的胎儿起源的兴趣广泛增长。这导致许多已发表的研究集中在子宫内暴露于物质和人类后代的结果。怀孕期间接触母体药物使用被认为是一种可预防的危害，因此是公共卫生关注和政策的主要问题。然而，在人类研究中的一个重要问题仍然是产前物质使用暴露是否具有致病作用的途径，以不利的发展和行为的结果，通过致畸作用，最近的见解和发展的研究方法将有助于充分和更精细的测试产前物质使用和后代的结果之间的关联。特别是，新的方法可以帮助从相关的风险因素中分离出接触物质的影响。因此，本手稿的目的是提供一个概述的方法学问题的研究，重点是在怀孕期间使用母体物质和后代的结果之间的关联，描述新的方法来测试这些协会，并提出一些新的和精心设计的研究的例子，并讨论他们的发现。(C)2009爱思唯尔公司版权所有
Interest in fetal origins of adverse offspring outcomes has grown extensively in the last decade. This has resulted in many published studies focusing on exposure in utero to substances and human offspring outcomes. Exposure to maternal substance use in pregnancy is believed to be a preventable hazard, and is therefore a main issue for public health concern and policy. However, an important question in human studies remains whether prenatal substance use exposure has an aetiological role in pathways to adverse developmental and behavioural outcomes via teratological effects.Recent insights and developments in research methodology will aid the adequate and more refined testing of associations between prenatal substance use and offspring outcomes. In particular, novel approaches could assist in disentangling the exposure to substance effects from correlated risk factors. The purpose of this manuscript is therefore to provide an overview of methodological issues involved in studies that focus on the association between maternal substance use during pregnancy and offspring's outcomes, to describe novel approaches to test these associations, and present some examples of new and well-designed studies and discuss their findings. (C) 2009 Elsevier Inc. All rights reserved