Prognosis of amyotrophic lateral sclerosis patients undergoing tracheostomy invasive ventilation therapy in Japan
Prognosis of amyotrophic lateral sclerosis patients undergoing tracheostomy invasive ventilation therapy in Japan
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DOI：
10.1136/jnnp-2019-322213
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发表时间：
2020-03-01
影响因子：
11
通讯作者：
Sobue, Gen
中科院分区：
文献类型：
--
作者：
Hayashi, Naoki;Atsuta, Naoki;Sobue, Gen
目的本研究的目的是描述和澄清的因素影响日本患者的肌萎缩侧索硬化症（ALS）进行气管切开有创通气（TIV）therapy.Methods的预后，我们进行了一项前瞻性纵向观察病例对照研究，采用多中心注册。纳入登记后开始TIV治疗的ALS患者（TIV组）和未接受TIV治疗的患者（非TIV组）。结果2006年2月至2018年1月，共纳入TIV组190例，非TIV组1093例。两组的平均发病年龄、胃造口术和无创通气治疗的使用率不同。在使用已知预后因素的倾向评分匹配分析中，TIV组的中位总生存时间显著大于非TIV组（11.33年vs 4.61年; p
Objective The aim of this study is to describe and clarify the factors affecting the prognosis of Japanese patients with amyotrophic lateral sclerosis (ALS) undergoing tracheostomy invasive ventilation (TIV) therapy.Methods We conducted a prospective longitudinal observational case-control study using a multicentre registry. ALS patients who started TIV therapy after registration (TIV group) and those who did not receive TIV (non-TIV group) were included. We compared the survival time between the TIV group and the non-TIV group using a propensity score matching analysis and evaluated the prognostic factors in the TIV group.Results From February 2006 to January 2018, 190 patients in the TIV group and 1093 patients in the non-TIV group were included in this study. The mean age of disease onset and usage rate of gastrostomy and non-invasive ventilation therapy differed between the groups. In the propensity score matching analysis using known prognostic factors, the median overall survival time of the TIV group was significantly greater than that of the non-TIV group (11.33 years vs 4.61 years; p