THE INTRAUTERINE AND EARLY POSTNATAL ORIGINS OF CARDIOVASCULAR-DISEASE AND CHRONIC-BRONCHITIS
THE INTRAUTERINE AND EARLY POSTNATAL ORIGINS OF CARDIOVASCULAR-DISEASE AND CHRONIC-BRONCHITIS
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DOI：
10.1136/jech.43.3.237
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发表时间：
1989-09-01
影响因子：
6.3
通讯作者：
LAW, CM
中科院分区：
文献类型：
--
作者：
BARKER, DJP;OSMOND, C;LAW, CM
英格兰和威尔士心血管疾病和慢性支气管炎死亡率的地理差异与过去婴儿死亡率的差异密切相关。本文考察了1968- 1978年期间死亡率与1911- 1925年期间新生儿和新生儿后期死亡率的单独关系。婴儿死亡率的这些分类分别是宫内和产后早期环境的指标。中风与新生儿死亡率有关，因此与宫内环境有关。产前血压水平的决定因素可能是其中的一个机制。支气管炎与出生后死亡率有关，因此与出生后环境有关。这可能反映了儿童早期下呼吸道感染的长期影响。缺血性心脏病与新生儿和新生儿后死亡率有关，因此与宫内和产后环境有关。这种联系可能包括血压和出生后早期建立的未知过程。
Geographical differences in mortality from cardiovascular disease and chronic bronchitis within England and Wales are closely related to past differences in infant mortality. This paper examines the separate relations of mortality during 1968-78 with neonatal and post-neonatal mortality during 1911-25. These divisions of infant mortality are indicators of the intrauterine and early postnatal environments respectively. Stroke is related to neonatal mortality and therefore to the intrauterine environment. Prenatal determinants of blood pressure levels may be one mechanism underlying this. Bronchitis is related to postnatal mortality and therefore to the postnatal environment. This may reflect the long term effects of lower respiratory tract infection in early childhood. Ischaemic heart disease is related to both neonatal and post-neonatal mortality and therefore to the intrauterine and postnatal environments. The links may include blood pressure and as yet unknown processes established in early postnatal life.