Protein Adsorption Resistance and Oxygen Permeability of Chemically Crosslinked Phospholipid Polymer Hydrogel for Ophthalmologic Biomaterials
Protein Adsorption Resistance and Oxygen Permeability of Chemically Crosslinked Phospholipid Polymer Hydrogel for Ophthalmologic Biomaterials
复制标题
DOI：
10.1002/jbm.b.31204
复制
发表时间：
2009-04-01
影响因子：
3.4
通讯作者：
Ishihara, Kazuhiko
中科院分区：
文献类型：
--
作者：
Goda, Tatsuro;Matsuno, Ryosuke;Ishihara, Kazuhiko
以2-甲基丙烯酰氧乙基磷胆碱(MPC)和新型交联剂2-(methacryloyloxy)ethyl-N-(2-methacryloyloxy)ethyl]磷胆碱(MMPC)为交联剂，制备了含磷酰胆碱基的聚合物水凝胶仿生结构，以制备生物相容性眼科材料。MMPC是一种具有磷酰胆碱类似键的二甲基丙烯酸酯。以前的报道阐明，MMPC对MPC的亲和力使聚(MPC)水凝胶的水含量和力学性能发生变化，而不会干扰主体相。在这项研究中，我们考察了机械增强聚(MPC)水凝胶的蛋白质吸附阻力、水的润湿性、透氧性和电解质渗透性。该凝胶对蛋白质的吸附量为0.9mug/cm(2)，占Omafilcon A和Etaficon A的30%和3%。水接触角实验表明，该凝胶具有良好的润湿性。所得凝胶的透氧率和氯化钠扩散常数分别为巴尔和48×10~(-6)cm~(-2)/S。这种高渗透性是由于高水分含量造成的，类似于人类角膜的情况。这些结果表明，聚(MPC)水凝胶在眼科生物材料中具有良好的应用潜力。(C)2008 Wiley期刊，Inc.生物材料资源B部分：APPL Biomater 89B：184-190,2009
The biomimetic structure of a polymer hydrogel bearing phosphorylcholine groups was obtained from 2-methacryloyloxyethylphosphorlcholline (MPC) and a novel crosslinker, 2-(methacryloyloxy)ethyl-N-(2-methacryloyloxy)ethyl] phosphorylcholine (MMPC), to prepare biocompatible ocular materials. MMPC is a dimethacrylate with phosphorylcholine-analogous linkage. Previous reports clarified that the affinity of MMPC to MPC enables the water contents and mechanical properties of the poly(MPC) hydrogels to be varied without disturbing the bulk phases. In this study, we examined the protein adsorption resistance, water wettability, oxygen permeability, and electrolyte permeability of the mechanically enhanced poly(MPC) hydrogel crosslinked with MMPC. The amount of protein adsorbed on this hydrogel was 0.9 mu g/cm(2), which accounted for 30% of Omafilcon A and 3% of Etafilcon A. Water contact angle experiments revealed the high wettability of the poly(MPC) hydrogels. The oxygen permeability and NaCl diffusion constant of the poly(MPC) hydrogels were 64 barrer and 48 x 10(-6) cm(2)/S, respectively. This high permeability resulted from the high water content, similar to the case of the human cornea. These results suggested that poly(MPC) hydrogels have good potential for use in ophthalmologic biomaterials. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 89B: 184-190, 2009