Measuring reward assessment in context: The effects of selective frontal or hippocampal lesions a semi-naturalistic amygdala, orbital frontal or hippocampal lesions
Measuring reward assessment in context: The effects of selective frontal or hippocampal lesions a semi-naturalistic amygdala, orbital frontal or hippocampal lesions
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DOI：
10.1016/j.neuroscience.2007.06.035
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发表时间：
2007-09-07
期刊：
影响因子：
3.3
通讯作者：
Bachevalier, J.
中科院分区：
文献类型：
--
作者：
Machado, C. J.;Bachevalier, J.
在人类、非人类灵长类动物和啮齿动物身上，研究复杂的目标导向行为(如社会行为、寻求奖励或逃避惩罚)背后的神经机制已变得越来越容易。然而，在大多数实验中，目标定向行为是在实验室环境中测量的，这与这些行为自然发生的背景非常不同，本研究采用了奖励评估范式，以前在威斯康星州通用测试仪(WGTA)的受控环境中对恒河猴(Macaca Mulatta)进行[Machado CJ，Bachvalier J(2007)]，研究选择性杏仁核、眼眶额叶皮质或海马结构损伤对非人类灵长类动物奖励评估的影响。EUJ Neurosci 25：2885-2904]，更自然的背景。我们使用这个新的范式来检测双侧杏仁核、海马体或眼眶额叶皮质损伤对既定的食物和非食物偏好的影响。还测量了增强剂贬值后的行为改变。与我们之前的研究一致，与手术前相比，所有的病变都没有引起对美味食物的偏好的变化，但杏仁核病变的动物表现出对不美味食物的高度偏好，而对照或其他手术动物通常会避免。与之前几个基于WGTA的实验不同，非食物偏好不受任何损伤的影响。最后，有眼眶额叶皮质损伤的动物在饱食后继续选择首选食物，但那些杏仁核、海马体或假损伤的动物适当地改变了它们的觅食行为，选择了较少的饱足食物。这些发现与这些动物在WGTA中进行测试时获得的食物贬值结果是平行的。总体而言，这项研究强调了在测量有选择性脑损伤的非人类灵长类动物的决策能力时测试背景的重要性。(C)2007年IBRO。爱思唯尔有限公司出版。保留所有权利。
Studying the neural mechanisms underlying complex goal-directed behaviors, such as social behavior, reward seeking or punishment avoidance, has become increasingly tractable in humans, nonhuman primates and rodents. In most experiments, however, goal-directed behaviors are measured in a laboratory setting, which is vastly different from the context in which these behaviors naturally occur, This study adapted a reward assessment paradigm, previously conducted with rhesus monkeys (Macaca mulatta) in the controlled environment of a Wisconsin General Testing Apparatus (WGTA) [Machado CJ, Bachevalier J (2007) The effects of selective amygdala, orbital frontal cortex or hippocampal formation lesions on reward assessment in nonhuman primates. Eur J Neurosci 25:2885-2904], to a more naturalistic context. We used this new paradigm to examine the effects of bilateral amygdaloid, hippocampal or orbital frontal cortex lesions on established food and nonfood preferences. Behavioral modification following reinforcer devaluation was also measured. Consistent with our previous study, none of the lesions produced changes in preference for palatable foods relative to pre-surgery, but animals with amygdala lesions displayed heightened preference for unpalatable foods that control or other operated animals typically avoided. In contrast to several previous WGTA-based experiments, nonfood preference was not affected by any of the lesions. Finally, animals with orbital frontal cortex lesions continued to select preferred foods after satiation, but those with amygdala, hippocampal or sham lesions altered their foraging behavior appropriately and selected less of the sated food. These findings parallel food devaluation results obtained with these same animals when tested in the WGTA. Overall, this study stresses the importance of testing context when measuring decision-making abilities in nonhuman primates with selective brain lesions. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.