Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells
Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells
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DOI：
10.1254/jphs.sc0060011
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发表时间：
2006-03-01
影响因子：
3.5
通讯作者：
Imaizumi, Y
中科院分区：
文献类型：
--
作者：
Morimura, K;Yamamura, H;Imaizumi, Y
We examined effects of small and intermediate conductance Ca2+-activated K+ (SK and IK) channel openers, DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) and NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), on L-type Ca2+ channel current (I-Ca) that was measured in smooth muscle cells isolated from mouse urinary bladder under whole cell voltage-clamp. The I-Ca was concentration-dependently inhibited by DCEBIO and NS309; half inhibition was obtained at 71.6 and 10.61 mu M, respectively. The specificity of NS309 to the IK channel over the Ca2+ channel appears to be high and higher than that of DCEBIO. DCEBIO and even NS309 may, however, substantially block Ca2+ channels when used as SK channel openers.
