Effects of alprazolam and imipramine on parasympathetic cardiac control in patients with generalized anxiety disorder.
Effects of alprazolam and imipramine on parasympathetic cardiac control in patients with generalized anxiety disorder.
复制标题
阿普唑仑和丙咪嗪对广泛性焦虑症患者副交感心脏控制的影响。
DOI：
10.1007/bf02245268
复制
发表时间：
1992
影响因子：
3.4
通讯作者：
Zimmerli,WD
中科院分区：
文献类型：
--
作者：
McLeod,DR;Hoehn-Saric,R;Porges,SW;Zimmerli,WD
A noninvasive measure was used to assess the effects of alprazolam, imipramine and placebo on parasympathetic (vagal) cardiac control following 6-weeks of medication in patients with generalized anxiety disorder. Flexible dosage at therapeutic levels resulted in increased heart rate and blood pressure and in decreased cardiac vagal control in patients receiving imipramine but not alprazolam or placebo. About 50% of the variance in heart rate changes and changes in mean arterial blood pressure following treatment with imipramine could be accounted for by changes in cardiac vagal control. Decreased cardiac vagal control can now be added to the list of cardiovascular changes seen following several weeks of treatment with imipramine.
