Sequence of human adenosine deaminase cDNA including the coding region and a small intron.
Sequence of human adenosine deaminase cDNA including the coding region and a small intron.
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人腺苷脱氨酶 cDNA 序列，包括编码区和一个小内含子。
DOI：
10.1093/nar/12.5.2439
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发表时间：
1984
影响因子：
14.9
通讯作者：
Hutton,JJ
中科院分区：
文献类型：
--
作者：
Wiginton,DA;Adrian,GS;Hutton,JJ
一个不寻常的，克隆的人腺苷脱氨酶cDNA的核苷酸序列已被确定。在1535个核苷酸的序列中包含1089个核苷酸的编码序列，其编码40，762道尔顿的蛋白质。编码序列被含有76个核苷酸的非编码区中断。该区域的3′端和5′端都具有通常与剪接位点相关的共有序列。3′端非翻译序列包含308个核苷酸，其中距离末端20个核苷酸处有一个多聚腺苷酸化信号序列。克隆的cDNA似乎对应于含有小内含子的核mRNA前体。
The nucleotide sequence for an unusual, cloned human adenosine deaminase cDNA has been determined. Contained within a sequence of 1535 nucleotides is a coding sequence of 1089 nucleotides that encodes a protein of 40,762 daltons. The coding sequence is interrupted by a non-coding region containing 76 nucleotides. Both the 3′ and 5′ ends of this region have consensus sequences generally associated with splice sites. The 3′ untranslated sequence contained 308 nucleotides, including a polyadenylation signal sequence 20 nucleotides from the end. The cloned cDNA appears to correspond to a nuclear mRNA precursor which contains a small intron.