Magnetic Fe3O4 nanoparticles coupled with a fluorescent Eu complex for dual imaging applications.
Magnetic Fe3O4 nanoparticles coupled with a fluorescent Eu complex for dual imaging applications.
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DOI：
10.1039/c2cc18122c
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发表时间：
2012-02
影响因子：
4.9
通讯作者：
Pinxian Xi;Kaia Cheng;Xiaolian Sun;Z. Zeng;Shouheng Sun
中科院分区：
文献类型：
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作者：
Pinxian Xi;Kaia Cheng;Xiaolian Sun;Z. Zeng;Shouheng Sun
合成了磁性8 nm Fe 3 O 4纳米粒子（NPs），并分别用多巴胺（DPA）和聚乙二醇（PEG）二酸对其进行修饰。然后将水溶性Fe（3）O（4）-DPA-PEG NP与Eu（iii）荧光配合物三（二苯甲酰甲烷）-5-氨基-1，10-菲咯啉（BMAP）偶联，得到Fe（3）O（4）-DPA-PEG-BMAP-Eu NP偶联物。该偶联物在磷酸盐缓冲溶液中具有胶体稳定性和化学稳定性，可用作磁共振和荧光成像的探针。
Magnetic 8 nm Fe(3)O(4) nanoparticles (NPs) were synthesized and modified with dopamine (DPA) and polyethylene glycol (PEG) diacid. The water soluble Fe(3)O(4)-DPA-PEG NPs were then conjugated with the fluorescent Eu(iii) complex of tris(dibenzoylmethane)-5-amino-1,10-phenanthroline (BMAP), giving an Fe(3)O(4)-DPA-PEG-BMAP-Eu NP conjugate. The conjugate was both colloidally and chemically stable in phosphate buffered solutions and could be used as a probe for magnetic resonance and fluorescent imaging.