Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure
Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure
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DOI：
10.1038/ncomms5821
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发表时间：
2014-09-01
影响因子：
16.6
通讯作者：
Pabst, Oliver
中科院分区：
文献类型：
--
作者：
Ugur, Milas;Schulz, Olga;Pabst, Oliver
效应性和记忆性CD4(+)T细胞根据免疫反应的类型和位置获得不同的迁移特性。由于T细胞循环的高度动态性质，对这些迁移途径的全面分析需要专门的实验方法。在这里，我们通过长期的体内细胞跟踪来分析效应/记忆CD4(+)T细胞的迁移。我们确定了一组常驻的有抗原经验的CD4(+)T细胞，这些细胞驻留在淋巴结和Peyer‘s斑块中，没有循环或增殖。常驻的CD4(+)T细胞占所有效应/记忆细胞的50%，包括但不限于滤泡辅助T细胞。此外，这些非循环T细胞具有独特的T细胞受体谱系，并在连续口服抗原暴露后聚集在Peyer‘s斑块中。我们的结果为淋巴组织中保留的效应/记忆性CD4(+)T细胞的常驻群体提供了第一个直接证据。
Effector and memory CD4(+) T cells acquire distinct migratory properties depending on the type and location of the immune responses. Due to the highly dynamic nature of T cell circulation, the comprehensive analysis of these migratory routes requires dedicated experimental approaches. Here, we analyse the migration of effector/memory CD4(+) T cells by long-term in vivo cell tracking. We identify a resident population of antigen-experienced CD4(+) T cells that resides in lymph nodes and Peyer's patches without circulation or proliferation. Resident CD4(+) T cells constitute up to 50% of all effector/memory cells, including, but not limited to, follicular helper T cells. Furthermore, these non-circulating T cells possess a distinct T cell receptor repertoire and accumulate in Peyer's patches after continuous oral antigen exposure. Our results provide the first direct evidence for a resident population of effector/memory CD4(+) T cells that is retained in lymphoid tissues.