Effect of elevated interstitial pressure on the renal cortical hemodynamics.
Effect of elevated interstitial pressure on the renal cortical hemodynamics.
复制标题
间质压升高对肾皮质血流动力学的影响。
DOI：
--
复制
发表时间：
1975
期刊：
影响因子：
--
通讯作者：
M. Wolgast
中科院分区：
文献类型：
--
作者：
O. Källskog;M. Wolgast
肾间质压力对浅表皮质血管内阻力模式的影响已经从测定1)用改良微球技术测定肾小球血流和2)血管内静水压力进行了研究。间质压力通过放置在囊下间隙的50毫米pvc导管监测。我们分析了两种情况，即a)输尿管压力升高至20毫米汞柱，b)静脉停滞至10-15毫米汞柱。这两种情况都使间质压力从1-2毫米汞柱升高至约5毫米汞柱，同时肝门淋巴流量和蛋白流量增加，大小大致相同。然而，血管的反应是不同的。输尿管停滞（但不是单个肾元停滞）导致传入小动脉阻力降低，同时肾小球毛细血管和肾小球周围毛细血管网络压力增加。相比之下，静脉停滞只对所研究的参数产生很小的变化，但管周毛细血管压力明显升高。结果表明，传入血管张力的调节不受间质压力的影响；管壁张力可能是这些因素之一。
The influence of renal interstitial pressure on the resistance pattern within the superficial cortical vasculature has been investigated from determinations of 1) the glomerular blood flow eith a modified microsphere technique and 2) the intravascular hydrostatic pressures. Interstitial pressure was monitored via a 50 mum PVC-catheter placed into the subcapsular interstitial space. Two conditions were analyzed viz. a) elevation of uretheral pressure to 20 mm Hg and b) venous stasis to 10-15 mm Hg. Both conditions produced an increase in the interstitial pressure from 1-2 mm Hg to about 5 mm Hg as well as an increased hilar lymph flow and protein flow of about the same size. The vascular reactions were different, however. Uretheral stasis (but not the stasis of a single nephron) produced a decreased resistance in the afferent arteriolae with a concomitant increae in the pressures in the glomerular capillaries, and the peritobular capillary network. In contrast, venous stasis produced only small changes in the parameters studied but for the obvious rise in the peritubular capillary pressure. The results suggest that factors other than the interstitial pressure are governing the afferent vascular tone; the tubular wall tension might be one of these factors.